A0A0K6GR57 · A0A0K6GR57_9BACI

Function

function

Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 2 Mg2+ ions per subunit.

Pathway

Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site42-44ATP (UniProtKB | ChEBI)
Binding site101-102ATP (UniProtKB | ChEBI)
Binding site135Mg2+ (UniProtKB | ChEBI)
Binding site174Mg2+ (UniProtKB | ChEBI)
Active site197
Binding site199D-ribose 5-phosphate (UniProtKB | ChEBI)
Binding site223D-ribose 5-phosphate (UniProtKB | ChEBI)
Binding site227-231D-ribose 5-phosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentribose phosphate diphosphokinase complex
Molecular FunctionATP binding
Molecular Functionkinase activity
Molecular Functionmagnesium ion binding
Molecular Functionribose phosphate diphosphokinase activity
Biological Process5-phosphoribose 1-diphosphate biosynthetic process
Biological Processphosphorylation
Biological Processpurine nucleotide biosynthetic process
Biological Processribonucleoside monophosphate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ribose-phosphate pyrophosphokinase
  • EC number
  • Short names
    RPPK
  • Alternative names
    • 5-phospho-D-ribosyl alpha-1-diphosphate synthase
    • Phosphoribosyl diphosphate synthase
    • Phosphoribosyl pyrophosphate synthase
      (P-Rib-PP synthase
      ; PRPP synthase
      ; PRPPase
      )

Gene names

    • Name
      prs
    • ORF names
      Ga0061060_11933

Organism names

Accessions

  • Primary accession
    A0A0K6GR57

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homohexamer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain9-125Ribose-phosphate pyrophosphokinase N-terminal

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    316
  • Mass (Da)
    34,621
  • Last updated
    2015-11-11 v1
  • Checksum
    D930D586903E8440
MSQYLNSNLKLFSLNSNPILAQEIAKVIGVELGKCSVSRFSDGEIQINIEESIRGCDVYVIQSTSAPVNEHLMELLIMIDALKRASAKTINIVMPYYGYARQDRKARSREPITAKLVANLLETAGASRVITLDLHAPQIQGFFDIPIDHLMGVPILADYFKEKQLDDIVIVSPDHGGVTRARKMADRLKAPIAIIDKRRPKPNVAEVMNIIGNVQGKTTILVDDIIDTAGTITLAANALAEHGAKEVYACCTHPVLSGPAIERIQNSKIKELVVTNTIAIPEEKKTNKIVELSVAPLIGEAIIRVHEEQSISALFD

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CYGZ01000019
EMBL· GenBank· DDBJ
CUA81016.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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