Study identified the mechanism that maintains presynaptic distribution during postdevelopmental growth; the requirement of a SLC17 family transporter CIMA-1. CIMA-1 antagonizes a specific FGFR isoform EGL-15(5A) in epidermal cells to modulate glial morphology in turn modulating AIY synaptic distribution.
Results show that N-glycans negatively regulate EGL-15 FGFR activity in vivo supporting the notion that mutation of N-glycosylation sites in human FGFR may lead to inappropriate activation of the receptor.
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