A0A0K3AV97 · A0A0K3AV97_CAEEL
- Protein1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
- Geneegl-8
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1378 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
function
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
Catalytic activity
- a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H+
Cofactor
Note: Binds 1 Ca2+ ion per subunit.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 327 | ||||
Binding site | 328 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 357 | Ca2+ (UniProtKB | ChEBI) | |||
Binding site | 359 | Ca2+ (UniProtKB | ChEBI) | |||
Active site | 375 | ||||
Binding site | 409 | Ca2+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | calcium ion binding | |
Molecular Function | phosphatidylinositol phospholipase C activity | |
Biological Process | intracellular signal transduction | |
Biological Process | lipid catabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
- EC number
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis
Accessions
- Primary accessionA0A0K3AV97
Proteomes
Organism-specific databases
Expression
Gene expression databases
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 482-572 | Disordered | |||
Compositional bias | 513-559 | Polar residues | |||
Compositional bias | 593-635 | Polar residues | |||
Region | 593-654 | Disordered | |||
Compositional bias | 636-654 | Basic and acidic residues | |||
Domain | 705-821 | PI-PLC Y-box | |||
Domain | 824-949 | C2 | |||
Region | 1019-1066 | Disordered | |||
Compositional bias | 1020-1059 | Polar residues | |||
Compositional bias | 1097-1113 | Basic and acidic residues | |||
Region | 1097-1123 | Disordered | |||
Region | 1135-1163 | Disordered | |||
Compositional bias | 1149-1163 | Polar residues | |||
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,378
- Mass (Da)155,156
- Last updated2015-11-11 v1
- Checksum552656DD6C1B6AC2
Computationally mapped potential isoform sequences
There are 22 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
G5EBH0 | PLCB_CAEEL | egl-8 | 1431 | ||
A0A0K3AS71 | A0A0K3AS71_CAEEL | egl-8 | 1500 | ||
A0A0K3AS74 | A0A0K3AS74_CAEEL | egl-8 | 1346 | ||
A0A0K3ARQ7 | A0A0K3ARQ7_CAEEL | egl-8 | 1394 | ||
A0A0K3ARR2 | A0A0K3ARR2_CAEEL | egl-8 | 1265 | ||
A0A0K3ARR7 | A0A0K3ARR7_CAEEL | egl-8 | 1391 | ||
A0A0K3AS80 | A0A0K3AS80_CAEEL | egl-8 | 1472 | ||
A0A0K3AS85 | A0A0K3AS85_CAEEL | egl-8 | 1297 | ||
A0A0K3AS90 | A0A0K3AS90_CAEEL | egl-8 | 1225 | ||
A0A0K3ARS4 | A0A0K3ARS4_CAEEL | egl-8 | 1318 | ||
A0A0K3AUL3 | A0A0K3AUL3_CAEEL | egl-8 | 1406 | ||
A0A0K3AUL7 | A0A0K3AUL7_CAEEL | egl-8 | 1334 | ||
A0A0K3AUM3 | A0A0K3AUM3_CAEEL | egl-8 | 1403 | ||
A0A0K3AUN1 | A0A0K3AUN1_CAEEL | egl-8 | 1285 | ||
A0A0K3AV83 | A0A0K3AV83_CAEEL | egl-8 | 1325 | ||
A0A0K3AV92 | A0A0K3AV92_CAEEL | egl-8 | 1253 | ||
A0A0K3AVA5 | A0A0K3AVA5_CAEEL | egl-8 | 1306 | ||
A0A0K3AXH8 | A0A0K3AXH8_CAEEL | egl-8 | 1512 | ||
A0A0K3AXI3 | A0A0K3AXI3_CAEEL | egl-8 | 1313 | ||
A0A0K3AXJ0 | A0A0K3AXJ0_CAEEL | egl-8 | 1484 | ||
A0A0K3AXJ6 | A0A0K3AXJ6_CAEEL | egl-8 | 1366 | ||
A0A0K3AXK2 | A0A0K3AXK2_CAEEL | egl-8 | 1237 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 513-559 | Polar residues | |||
Compositional bias | 593-635 | Polar residues | |||
Compositional bias | 636-654 | Basic and acidic residues | |||
Compositional bias | 1020-1059 | Polar residues | |||
Compositional bias | 1097-1113 | Basic and acidic residues | |||
Compositional bias | 1149-1163 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BX284605 EMBL· GenBank· DDBJ | CTQ86727.1 EMBL· GenBank· DDBJ | Genomic DNA |