A0A0K3AV97 · A0A0K3AV97_CAEEL

  • Protein
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
  • Gene
    egl-8
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    2/5

Function

function

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.

Catalytic activity

Cofactor

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Note: Binds 1 Ca2+ ion per subunit.

Features

Showing features for active site, binding site.

113781002003004005006007008009001,0001,1001,2001,300
Type
IDPosition(s)Description
Active site327
Binding site328Ca2+ (UniProtKB | ChEBI)
Binding site357Ca2+ (UniProtKB | ChEBI)
Binding site359Ca2+ (UniProtKB | ChEBI)
Active site375
Binding site409Ca2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functioncalcium ion binding
Molecular Functionphosphatidylinositol phospholipase C activity
Biological Processintracellular signal transduction
Biological Processlipid catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase
  • EC number

Gene names

    • Name
      egl-8
    • ORF names
      B0348.4
      , CELE_B0348.4

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Bristol N2
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis

Accessions

  • Primary accession
    A0A0K3AV97

Proteomes

Organism-specific databases

Expression

Gene expression databases

Structure

3D structure databases

Family & Domains

Features

Showing features for region, compositional bias, domain.

Type
IDPosition(s)Description
Region482-572Disordered
Compositional bias513-559Polar residues
Compositional bias593-635Polar residues
Region593-654Disordered
Compositional bias636-654Basic and acidic residues
Domain705-821PI-PLC Y-box
Domain824-949C2
Region1019-1066Disordered
Compositional bias1020-1059Polar residues
Compositional bias1097-1113Basic and acidic residues
Region1097-1123Disordered
Region1135-1163Disordered
Compositional bias1149-1163Polar residues

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,378
  • Mass (Da)
    155,156
  • Last updated
    2015-11-11 v1
  • Checksum
    552656DD6C1B6AC2
MAKEFQFNWKPTIIPELLHGSVFDRYDDESTCLELNAQVRIDENGFFLRWLIEGKDAVVLDMGQIWEARTGGLPKDGRIMFELEQRGASETIAERTIWITHGQDLVNVQSFFLVAESVELAKTCRAGINDILKSSRIRHVCPTTQLMKYHTWLTMNVNERRKIPIKLIIKTFSSGKPEKMVQKCLNDLGLGGDKEREELDVDILTFEKFQRLYNKICPRTEVQELFVKLSGQKEYLTKERLINFLNEEQRDPRLNEILFPFFDSQRIVALLKKHENDIKYQEDGKMSGDGFLRFLMSDENPPVFLDRIEMFMDMDQPLCHYYINSSHNTYLTGRQYGGKSSSEIYRQVLLSGCRCIELDCWDGTGENKGEPIITHGKAMCTDVFFKDVLVQIRDTAFARSDFPVVLSFENHCSKSNQLKMAKYCMDIFGDMLLSKPFEDAPLDPGVSLPSPNRLRKKILIKNKRLKTDIERHQLDQFLREGKLDEEDELNETPEVVGEDSVSPPGDQRAHPEVEQPVSSSSPATPSISGPPPCATSSGSTSSITITTTGCSTSSSGPSKHILGGEMPAKENDEAHPELKQNFIAKNLKGFGFSKKQPDSSTSLLTASPTPSSSSMAMSNANNPFSSSTLNSPQPMERSRSEKRSFRQKKGGVFGDELHSDSAALIDFMRTASSRKKKPVLTKEEEERIFAEYHYTGATTNIHPLLSSLVNYTHPVKFSGFDVAEANNLHFHMSSFSESTGLGYLKQSAPEFVNYNKRQSSRIYPKGARVDSSNFLPQIFWNAGCQMVSLNFQTPDVYMQLNMGKFEYNGGSGYLLKPDFLRRPDRTFDPFSESPVDGVIAAHCSVRVISGQFLSDRKIGTYVEVEMYGLPTDTIRKEHKTKVIPGNGLNPVYNEDPFVFRKVVLPELAVLRFAVYDENGKQLGQRILPLDGLQAGYRHISLRSDTNQSFILSPVLFVQIVIKTYVPDELSGLVDALADPRAFLSEQKKRQEALAHMGVDDSDIPDVPNTRNMALRHVKQPPRQNGSSADLLANNGQTGSARGDQTSSMASSTIRSPNEQPQPVAVDKFKVDPIEVDDLRRDKAFAKLLKRFQKELDDLRKKHQKQRDSIQKQQPARRRNSSIAWIQTNVDKLITNNRRSTKKEKGSRRSLTASVSSGCGSASGTVTVSVCSPSGASCSGYSTGGPSTPVACNSDGTGSPATIGSPVPQDLVNNDRVRSLVNTQTGEWSAMVRRHDEEEFELKKVQLKEQFDLLRKLMSEAQKNQMLALKLRLEAEGKDLKQTQTKKSMEDAKVIQLDKGIKTKAERDRRVKELNEKNLKMFVEERKRLAMKAQKHEEQLTKRHLDQLEQLDKDFHKALDAEVGNYKEEQLAAQPTSVV

Computationally mapped potential isoform sequences

There are 22 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
G5EBH0PLCB_CAEELegl-81431
A0A0K3AS71A0A0K3AS71_CAEELegl-81500
A0A0K3AS74A0A0K3AS74_CAEELegl-81346
A0A0K3ARQ7A0A0K3ARQ7_CAEELegl-81394
A0A0K3ARR2A0A0K3ARR2_CAEELegl-81265
A0A0K3ARR7A0A0K3ARR7_CAEELegl-81391
A0A0K3AS80A0A0K3AS80_CAEELegl-81472
A0A0K3AS85A0A0K3AS85_CAEELegl-81297
A0A0K3AS90A0A0K3AS90_CAEELegl-81225
A0A0K3ARS4A0A0K3ARS4_CAEELegl-81318
A0A0K3AUL3A0A0K3AUL3_CAEELegl-81406
A0A0K3AUL7A0A0K3AUL7_CAEELegl-81334
A0A0K3AUM3A0A0K3AUM3_CAEELegl-81403
A0A0K3AUN1A0A0K3AUN1_CAEELegl-81285
A0A0K3AV83A0A0K3AV83_CAEELegl-81325
A0A0K3AV92A0A0K3AV92_CAEELegl-81253
A0A0K3AVA5A0A0K3AVA5_CAEELegl-81306
A0A0K3AXH8A0A0K3AXH8_CAEELegl-81512
A0A0K3AXI3A0A0K3AXI3_CAEELegl-81313
A0A0K3AXJ0A0A0K3AXJ0_CAEELegl-81484
A0A0K3AXJ6A0A0K3AXJ6_CAEELegl-81366
A0A0K3AXK2A0A0K3AXK2_CAEELegl-81237

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias513-559Polar residues
Compositional bias593-635Polar residues
Compositional bias636-654Basic and acidic residues
Compositional bias1020-1059Polar residues
Compositional bias1097-1113Basic and acidic residues
Compositional bias1149-1163Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BX284605
EMBL· GenBank· DDBJ
CTQ86727.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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