A0A0K3ASP4 · A0A0K3ASP4_CAEEL
- ProteinVoltage-dependent T-type calcium channel subunit alpha
- Genecca-1
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1859 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | neuron projection | |
Cellular Component | voltage-gated calcium channel complex | |
Cellular Component | voltage-gated sodium channel complex | |
Molecular Function | low voltage-gated calcium channel activity | |
Molecular Function | metal ion binding | |
Biological Process | calcium ion import | |
Biological Process | membrane depolarization during action potential | |
Biological Process | neuronal action potential | |
Biological Process | sodium ion transmembrane transport |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameVoltage-dependent T-type calcium channel subunit alpha
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis
Accessions
- Primary accessionA0A0K3ASP4
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 174-193 | Helical | ||||
Sequence: IFVYFAFEMVIKIMALGFYG | ||||||
Transmembrane | 267-290 | Helical | ||||
Sequence: VLLLCFFVFFIFGIVGVQLWAGLL | ||||||
Transmembrane | 391-409 | Helical | ||||
Sequence: VSFDNIGFAWVAIFLVISL | ||||||
Transmembrane | 429-455 | Helical | ||||
Sequence: IYFVLLIVIGAFFMINLCLVVIATQFA | ||||||
Transmembrane | 690-710 | Helical | ||||
Sequence: LFFTALFALEMLLKIIASGLF | ||||||
Transmembrane | 778-799 | Helical | ||||
Sequence: FFGLLVLFIFIFSTLGMVLFGC | ||||||
Transmembrane | 863-889 | Helical | ||||
Sequence: ALYFVALMTFGNYVLFNLLVAILVEGF | ||||||
Transmembrane | 1119-1137 | Helical | ||||
Sequence: WFDYTVLFFIGINCITLAM | ||||||
Transmembrane | 1157-1178 | Helical | ||||
Sequence: YIFTVIFTGEMMMKVIANGCFI | ||||||
Transmembrane | 1190-1209 | Helical | ||||
Sequence: ILDGILVVISLINIAFELLA | ||||||
Transmembrane | 1255-1277 | Helical | ||||
Sequence: IGNIVLICCTFFIIFGILGVQLF | ||||||
Transmembrane | 1358-1381 | Helical | ||||
Sequence: MIYFISFLLLVGFFVLNMFVGVVV | ||||||
Transmembrane | 1464-1485 | Helical | ||||
Sequence: YFDLAIAAVIGINVISMAMEFY | ||||||
Transmembrane | 1497-1515 | Helical | ||||
Sequence: ALNYFFTAVFTLEAAMKLI | ||||||
Transmembrane | 1527-1545 | Helical | ||||
Sequence: WNRLDMFIVILSIAGIIFE | ||||||
Transmembrane | 1594-1613 | Helical | ||||
Sequence: VGNLGSLFFLLFFIFAALGV | ||||||
Transmembrane | 1682-1707 | Helical | ||||
Sequence: ILAPCFFVIFVLISQFVLVNVVVAVL |
Keywords
- Cellular component
Expression
Gene expression databases
Family & Domains
Features
Showing features for region, compositional bias, domain, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 18-85 | Disordered | ||||
Sequence: YAGGPRSVLGRRTSAITVNRRQSQSTRRHEDVEALGSIEGSKETLQLSEHGRLASSSEASPSRWEGRQ | ||||||
Compositional bias | 40-54 | Basic and acidic residues | ||||
Sequence: SQSTRRHEDVEALGS | ||||||
Compositional bias | 58-80 | Polar residues | ||||
Sequence: SKETLQLSEHGRLASSSEASPSR | ||||||
Domain | 130-461 | Ion transport | ||||
Sequence: PWFDRITMAVIMINCVTLGMYRPCEDGPDCDTYRCQILDIIDNCIFVYFAFEMVIKIMALGFYGPAAYMSDTWNRLDFFIVMAGIAEFVLHEYLGGNINLTAIRTVRVLRPLRAVNRIPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCVINLPKTISENQSALFNNVKLTRFYIPEDTSLEYICSQPDANGLHTCSNLPPYTVDGVKCNLTLDEYDKVTNDSCINWNIYYNECQVMQRNPFQGSVSFDNIGFAWVAIFLVISLEGWTDIMYYVQDAHSFWNWIYFVLLIVIGAFFMINLCLVVIATQFAETKRRE | ||||||
Compositional bias | 523-554 | Basic and acidic residues | ||||
Sequence: YMEERAERKSSERQQRRKSKLDDMATLSRIEE | ||||||
Region | 523-630 | Disordered | ||||
Sequence: YMEERAERKSSERQQRRKSKLDDMATLSRIEEKAEDEEDETTITRENGDDQIEQNGDGVRIKRVKIEEEPKIKIGNGNSNGPHYKHSSSDEESDEDGEEDQVYDGEEA | ||||||
Compositional bias | 567-594 | Basic and acidic residues | ||||
Sequence: RENGDDQIEQNGDGVRIKRVKIEEEPKI | ||||||
Domain | 656-896 | Ion transport | ||||
Sequence: TRGILVAILVNTLSMGVEYHQQPEILTVILEYSNLFFTALFALEMLLKIIASGLFGYLADGFNLFDGGIVALSVLELFQEGKGGLSVLRTFRLLRILKLVRFMPALRYQLVVMLRTMDNVTVFFGLLVLFIFIFSTLGMVLFGCKFCNHPDTGLQCTSAQVISSICECDRMNFDNFLFATVTVFQILTQEDWNMVLFNGMAQTNPWAALYFVALMTFGNYVLFNLLVAILVEGFQESKEEE | ||||||
Coiled coil | 886-917 | |||||
Sequence: VEGFQESKEEEKRQLEEDARKQAVEEEDERKR | ||||||
Region | 934-970 | Disordered | ||||
Sequence: GVAPAECTCQRPSSPEESPSPRLLSANYHPSPERKHS | ||||||
Compositional bias | 944-958 | Polar residues | ||||
Sequence: RPSSPEESPSPRLLS | ||||||
Coiled coil | 1052-1079 | |||||
Sequence: REKFLEASQELKQALAEEEKRNEAKQNT | ||||||
Domain | 1118-1390 | Ion transport | ||||
Sequence: KWFDYTVLFFIGINCITLAMERPSIPPDSFERQFLHISGYIFTVIFTGEMMMKVIANGCFIGQAAYFKDGWNILDGILVVISLINIAFELLATGDSPKIFGVIRVLRLLRALRPLRVINRAPGVKLVVMTLISSLKPIGNIVLICCTFFIIFGILGVQLFKGMMYHCIGPEVGNVTTKADCIEDYRNKWVNHRYNFDNLGQALMSLFVLSSKDGWVSIMYQGIDAVGVDVQPIENYNEWRMIYFISFLLLVGFFVLNMFVGVVVENFHKCKEA | ||||||
Coiled coil | 1381-1411 | |||||
Sequence: VENFHKCKEALEKEMREKEKEKRLKRKLKRQ | ||||||
Domain | 1462-1717 | Ion transport | ||||
Sequence: SKYFDLAIAAVIGINVISMAMEFYMMPMGLKYVLKALNYFFTAVFTLEAAMKLIALGFKRFFIEKWNRLDMFIVILSIAGIIFEEFEALELPINPTIIRVMRVLRIARVLKLLKMAKGIRSLLDTVGEALPQVGNLGSLFFLLFFIFAALGVELFGKLECSEDHPCDGLGEHAHFKNFGMAFLTLFRIATGDNWNGIMKDALRDDCDSSDHCETNCCVDPILAPCFFVIFVLISQFVLVNVVVAVLMKHLEESNKR | ||||||
Region | 1715-1740 | Disordered | ||||
Sequence: NKRDAEGPAEPTGENIENEITKSDDD | ||||||
Region | 1754-1779 | Disordered | ||||
Sequence: VKEGELDEEEETEEGPTTQIPDGHGG | ||||||
Region | 1810-1859 | Disordered | ||||
Sequence: LGGELQPLNPGEIEDLDDPEFRPRSRSHRPRARTNSALSNKSRGSHKSAL | ||||||
Compositional bias | 1841-1859 | Polar residues | ||||
Sequence: ARTNSALSNKSRGSHKSAL |
Sequence similarities
Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,859
- Mass (Da)212,362
- Last updated2015-11-11 v1
- ChecksumFB7AC5E33E9C2DDD
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 40-54 | Basic and acidic residues | ||||
Sequence: SQSTRRHEDVEALGS | ||||||
Compositional bias | 58-80 | Polar residues | ||||
Sequence: SKETLQLSEHGRLASSSEASPSR | ||||||
Compositional bias | 523-554 | Basic and acidic residues | ||||
Sequence: YMEERAERKSSERQQRRKSKLDDMATLSRIEE | ||||||
Compositional bias | 567-594 | Basic and acidic residues | ||||
Sequence: RENGDDQIEQNGDGVRIKRVKIEEEPKI | ||||||
Compositional bias | 944-958 | Polar residues | ||||
Sequence: RPSSPEESPSPRLLS | ||||||
Compositional bias | 1841-1859 | Polar residues | ||||
Sequence: ARTNSALSNKSRGSHKSAL |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
BX284606 EMBL· GenBank· DDBJ | CTQ87048.1 EMBL· GenBank· DDBJ | Genomic DNA |