A0A0K3ASP4 · A0A0K3ASP4_CAEEL

  • Protein
    Voltage-dependent T-type calcium channel subunit alpha
  • Gene
    cca-1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.

Features

Showing features for binding site.

118592004006008001,0001,2001,4001,6001,800
TypeIDPosition(s)Description
Binding site410Ca2+ (UniProtKB | ChEBI)
Binding site845Ca2+ (UniProtKB | ChEBI)
Binding site1789Ca2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentneuron projection
Cellular Componentvoltage-gated calcium channel complex
Cellular Componentvoltage-gated sodium channel complex
Molecular Functionlow voltage-gated calcium channel activity
Molecular Functionmetal ion binding
Biological Processcalcium ion import
Biological Processmembrane depolarization during action potential
Biological Processneuronal action potential
Biological Processsodium ion transmembrane transport

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Voltage-dependent T-type calcium channel subunit alpha

Gene names

    • Name
      cca-1
    • ORF names
      C54D2.5
      , CELE_C54D2.5

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Bristol N2
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis

Accessions

  • Primary accession
    A0A0K3ASP4

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane174-193Helical
Transmembrane267-290Helical
Transmembrane391-409Helical
Transmembrane429-455Helical
Transmembrane690-710Helical
Transmembrane778-799Helical
Transmembrane863-889Helical
Transmembrane1119-1137Helical
Transmembrane1157-1178Helical
Transmembrane1190-1209Helical
Transmembrane1255-1277Helical
Transmembrane1358-1381Helical
Transmembrane1464-1485Helical
Transmembrane1497-1515Helical
Transmembrane1527-1545Helical
Transmembrane1594-1613Helical
Transmembrane1682-1707Helical

Keywords

  • Cellular component

Expression

Gene expression databases

Structure

3D structure databases

Family & Domains

Features

Showing features for region, compositional bias, domain, coiled coil.

Type
IDPosition(s)Description
Region18-85Disordered
Compositional bias40-54Basic and acidic residues
Compositional bias58-80Polar residues
Domain130-461Ion transport
Compositional bias523-554Basic and acidic residues
Region523-630Disordered
Compositional bias567-594Basic and acidic residues
Domain656-896Ion transport
Coiled coil886-917
Region934-970Disordered
Compositional bias944-958Polar residues
Coiled coil1052-1079
Domain1118-1390Ion transport
Coiled coil1381-1411
Domain1462-1717Ion transport
Region1715-1740Disordered
Region1754-1779Disordered
Region1810-1859Disordered
Compositional bias1841-1859Polar residues

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,859
  • Mass (Da)
    212,362
  • Last updated
    2015-11-11 v1
  • Checksum
    FB7AC5E33E9C2DDD
MLRQPVPELRSFQSLSKYAGGPRSVLGRRTSAITVNRRQSQSTRRHEDVEALGSIEGSKETLQLSEHGRLASSSEASPSRWEGRQIEWGNEEQIEEESELPYPGFAEPALRCFYQARPPRKWALQMVMSPWFDRITMAVIMINCVTLGMYRPCEDGPDCDTYRCQILDIIDNCIFVYFAFEMVIKIMALGFYGPAAYMSDTWNRLDFFIVMAGIAEFVLHEYLGGNINLTAIRTVRVLRPLRAVNRIPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCVINLPKTISENQSALFNNVKLTRFYIPEDTSLEYICSQPDANGLHTCSNLPPYTVDGVKCNLTLDEYDKVTNDSCINWNIYYNECQVMQRNPFQGSVSFDNIGFAWVAIFLVISLEGWTDIMYYVQDAHSFWNWIYFVLLIVIGAFFMINLCLVVIATQFAETKRRETERMLQERKMLLNRDSISCTGSEIGGASSKEEGDTVYAAFVRFIGHTFRRTKRAAKKKYTAYMEERAERKSSERQQRRKSKLDDMATLSRIEEKAEDEEDETTITRENGDDQIEQNGDGVRIKRVKIEEEPKIKIGNGNSNGPHYKHSSSDEESDEDGEEDQVYDGEEAKKKSTPSKLWWFREKIQKFVICDHFTRGILVAILVNTLSMGVEYHQQPEILTVILEYSNLFFTALFALEMLLKIIASGLFGYLADGFNLFDGGIVALSVLELFQEGKGGLSVLRTFRLLRILKLVRFMPALRYQLVVMLRTMDNVTVFFGLLVLFIFIFSTLGMVLFGCKFCNHPDTGLQCTSAQVISSICECDRMNFDNFLFATVTVFQILTQEDWNMVLFNGMAQTNPWAALYFVALMTFGNYVLFNLLVAILVEGFQESKEEEKRQLEEDARKQAVEEEDERKRELELIIAKTTSPAFNNGVAPAECTCQRPSSPEESPSPRLLSANYHPSPERKHSANLDAIIDKRLVLRNSAPFDRSPVSEGRDDSRLNRHASLVLPVANGVPYRRQRVHSWSGLCHHFNPNCPVHGRRALIETYAREKFLEASQELKQALAEEEKRNEAKQNTFVRKLLKKTCLHNRTEFSLFLMGPKNPLRIKCLQTTQKKWFDYTVLFFIGINCITLAMERPSIPPDSFERQFLHISGYIFTVIFTGEMMMKVIANGCFIGQAAYFKDGWNILDGILVVISLINIAFELLATGDSPKIFGVIRVLRLLRALRPLRVINRAPGVKLVVMTLISSLKPIGNIVLICCTFFIIFGILGVQLFKGMMYHCIGPEVGNVTTKADCIEDYRNKWVNHRYNFDNLGQALMSLFVLSSKDGWVSIMYQGIDAVGVDVQPIENYNEWRMIYFISFLLLVGFFVLNMFVGVVVENFHKCKEALEKEMREKEKEKRLKRKLKRQKFEESMAGKRKKNRIVWAGSAIKSIFSVERNYPYYHDYGHTRLFLHGIVTSKYFDLAIAAVIGINVISMAMEFYMMPMGLKYVLKALNYFFTAVFTLEAAMKLIALGFKRFFIEKWNRLDMFIVILSIAGIIFEEFEALELPINPTIIRVMRVLRIARVLKLLKMAKGIRSLLDTVGEALPQVGNLGSLFFLLFFIFAALGVELFGKLECSEDHPCDGLGEHAHFKNFGMAFLTLFRIATGDNWNGIMKDALRDDCDSSDHCETNCCVDPILAPCFFVIFVLISQFVLVNVVVAVLMKHLEESNKRDAEGPAEPTGENIENEITKSDDDEIVEEHEPLAIEHVKEGELDEEEETEEGPTTQIPDGHGGIKRLSMQVLEQELIEVERHLEERYRRASECLGGELQPLNPGEIEDLDDPEFRPRSRSHRPRARTNSALSNKSRGSHKSAL

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
Q7Z003Q7Z003_CAEELcca-11885
Q7YZR6Q7YZR6_CAEELcca-11844
G5EBS2G5EBS2_CAEELcca-11837
Q7Z002Q7Z002_CAEELcca-11852

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias40-54Basic and acidic residues
Compositional bias58-80Polar residues
Compositional bias523-554Basic and acidic residues
Compositional bias567-594Basic and acidic residues
Compositional bias944-958Polar residues
Compositional bias1841-1859Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BX284606
EMBL· GenBank· DDBJ
CTQ87048.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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