A0A0K0Y1B4 · A0A0K0Y1B4_9RHOB

  • Protein
    Dihydrofolate synthase/folylpolyglutamate synthase
  • Gene
    fgs
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10-formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives.

Catalytic activity

Pathway

Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 2/2.
Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular Functiondihydrofolate synthase activity
Molecular Functionmetal ion binding
Molecular Functiontetrahydrofolylpolyglutamate synthase activity
Biological Processcell division
Biological Processcell wall organization
Biological Processfolic acid biosynthetic process
Biological Processpeptidoglycan biosynthetic process
Biological Processregulation of cell shape
Biological Processtetrahydrofolate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Dihydrofolate synthase/folylpolyglutamate synthase
  • EC number
  • Alternative names
    • Folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase
    • Folylpolyglutamate synthetase
    • Tetrahydrofolylpolyglutamate synthase

Gene names

    • Name
      fgs
    • ORF names
      OSB_01220

Organism names

  • Taxonomic identifier
  • Strain
    • SB1
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Alphaproteobacteria > Rhodobacterales > Roseobacteraceae > Octadecabacter

Accessions

  • Primary accession
    A0A0K0Y1B4

Proteomes

Subcellular Location

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain47-262Mur ligase central
Domain295-410Mur ligase C-terminal

Sequence similarities

Belongs to the folylpolyglutamate synthase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    422
  • Mass (Da)
    45,128
  • Last updated
    2015-11-11 v1
  • Checksum
    3B4908AF901F773E
MTQKSDQILERMMALHPKIIDLTLDRMWRLLNALGNPERRLPPVIHIAGTNGKGSTQAMIRAGLEAQGKRVHAYTSPHLARFHERIRLAGQLISEEALTEALDRCYAANNGETITYFEITTCAAILAFAETPADYTLLEVGLGGRLDATNVIDPALSIITPIDLDHQQFLGDTLPEIAAEKAGIIKRGVPCIVGPQHDDAMDVIETKAARLGAPLIAYGQHFHVSQERDRLIYQDETGLLDLPLPALRGPHQVQNAGAVLAALRHLGADESACEAALTDATWPARMERLTTGPLVERCAPAELWLDGGHNPAAGKAISATLATLPKRPTHVICGMLNTKDVAGFMTPLAPHVQSLIAVAIPGEANTLPAQTTADAATSAGISATTAESLDIALDAILATEPNARILICGSLYFAGHVMRENV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP012160
EMBL· GenBank· DDBJ
AKS44691.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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