A0A0K0PKU5 · A0A0K0PKU5_9APIC

  • Protein
    Cytochrome c oxidase subunit 1
  • Gene
    cox1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Pathway

Energy metabolism; oxidative phosphorylation.

GO annotations

AspectTerm
Cellular Componentmitochondrial respiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number

Gene names

    • Name
      cox1

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • 47
  • Taxonomic lineage
    Eukaryota > Sar > Alveolata > Apicomplexa > Aconoidasida > Haemosporida > Plasmodiidae > Plasmodium > Plasmodium (Plasmodium)

Accessions

  • Primary accession
    A0A0K0PKU5

Organism-specific databases

Subcellular Location

Membrane
; Multi-pass membrane protein
Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane20-38Helical
Transmembrane107-127Helical
Transmembrane147-171Helical
Transmembrane192-216Helical
Transmembrane249-266Helical
Transmembrane278-296Helical
Transmembrane308-333Helical
Transmembrane345-369Helical
Transmembrane381-402Helical
Transmembrane414-437Helical
Transmembrane457-475Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain2-476Cytochrome oxidase subunit I profile

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    476
  • Mass (Da)
    52,868
  • Last updated
    2015-11-11 v1
  • Checksum
    3050521F019F61A0
FVFNRYTLITNCNHKTLGLYYLWFSFLFGSYGFLLSVILRTELYSSSLRIIAQENVNLYNMIFTLHGIIMIFFNIMPGLFGGFGNYFLPILCGSPELAYPRINSISLLLQPIAFILVILSTAAEFGGGTGWTLYPPLSTSLMSLSPVAVDVIIVGLLVSGIASIMSSLNFITTVMHLRSKGLTLGILSVSTWSLIITSVMLLLTLPVLTGGVLMLLSDLHFNTLFFDPTFAGDPILYQHLFWFFGHPEVYILILPAFGVISHVISTNYCRSLFGNQSMILAMSCIAILGSVVWAHHMYTTGLEVDTRAFFTSTTILISIPTGTKIFNWICTYMGSNFGITHSSSLLSLLFICTFTFGGTTGVILGNAAIDIALHDTYYVIAHFHFVLSIGAIIALFTLVSSFQENFFGKHLRENSIIILWSILFFIGVVLTFLPMHFLGFNVMPRRIPDYPDALNGWNMICSIGSTMTLFGLFIFK

Features

Showing features for non-terminal residue.

TypeIDPosition(s)Description
Non-terminal residue1

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KJ569865
EMBL· GenBank· DDBJ
AKQ33070.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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