A0A0K0MBN4 · A0A0K0MBN4_9CALI
- ProteinGenome polyprotein
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1699 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
function
3C-like protease processes the polyprotein: 3CLpro-RdRp is first released by autocleavage, then all other proteins are cleaved. May cleave polyadenylate-binding protein thereby inhibiting cellular translation.
Catalytic activity
- a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H+
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 1038 | For 3CLpro activity | ||||
Sequence: H | ||||||
Active site | 1062 | For 3CLpro activity | ||||
Sequence: E | ||||||
Active site | 1147 | For 3CLpro activity | ||||
Sequence: C |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | cysteine-type endopeptidase activity | |
Molecular Function | RNA binding | |
Molecular Function | RNA helicase activity | |
Molecular Function | RNA-dependent RNA polymerase activity | |
Biological Process | DNA-templated transcription | |
Biological Process | proteolysis | |
Biological Process | RNA-protein covalent cross-linking | |
Biological Process | viral RNA genome replication |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameGenome polyprotein
Organism names
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Pisuviricota > Pisoniviricetes > Picornavirales > Caliciviridae > Norovirus > Norwalk virus
Accessions
- Primary accessionA0A0K0MBN4
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Post-translational modification
Specific enzymatic cleavages in vivo yield mature proteins. 3CLpro is first autocatalytically cleaved, then processes the whole polyprotein.
Keywords
- PTM
Structure
Family & Domains
Features
Showing features for region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-78 | Disordered | ||||
Sequence: MKMASTDASAAAVAISNNDTAKSSSDGVLSSMAVTFKRALGARPKQPPPREKPQRPPRPPTPELVKNIPPPPPNGEDE | ||||||
Compositional bias | 10-31 | Polar residues | ||||
Sequence: AAAVAISNNDTAKSSSDGVLSS | ||||||
Compositional bias | 53-76 | Pro residues | ||||
Sequence: PQRPPRPPTPELVKNIPPPPPNGE | ||||||
Region | 95-118 | Disordered | ||||
Sequence: LSTVRQPEESNTAFSVPPLNQREN | ||||||
Compositional bias | 97-113 | Polar residues | ||||
Sequence: TVRQPEESNTAFSVPPL | ||||||
Domain | 465-632 | SF3 helicase | ||||
Sequence: LARIAAARSLVHRAKEELSSRPRPVVLMISGRPGIGKTHLAREVAKRIAASLTGDQRVGLIPRNGVDHWDAYKGERVVLWDDYGMSNPIHDALRLQELADTCPLTLNCDRIENKGKVFDSDVIIITTNLANPAPLDYVNFEACSRRIDFLVYAEAPEVEKAKRDFPGQ | ||||||
Region | 843-862 | Disordered | ||||
Sequence: QVENTEETTSKDGCPKPKDD | ||||||
Compositional bias | 847-862 | Basic and acidic residues | ||||
Sequence: TEETTSKDGCPKPKDD | ||||||
Region | 874-895 | Disordered | ||||
Sequence: AEGKKGKNKTGRGKKHTAFSSK | ||||||
Domain | 1009-1189 | Peptidase C37 | ||||
Sequence: APPSIWSRIVNFGSGWGFWVSPSLFITSTHVIPQGAKEFFGVPIKQIQVHKSGEFCRLRFPKPIRTDVTGMILEEGAPEGTVVTLLIKRSTGELMPLAARMGTHATMKIQGRTVGGQMGMLLTGSNAKSMDLGTTPGDCGCPYIYKRGNDYVVIGVHTAAARGGNTVICATQGSEGEATLE | ||||||
Domain | 1425-1546 | RdRp catalytic | ||||
Sequence: TYHYDADYSRWDSTQQRAVLAAALEIMVKFSPEPHLAQVVAEDLLSPSVVDVGDFTISINEGLPSGVPCTSQWNSIAHWLLTLCALSEVTNLSPDTIQANSLFSFYGDDEIVSTDIKLDPEK |
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,699
- Mass (Da)188,801
- Last updated2015-11-11 v1
- Checksum0ED02054D76A624B
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 10-31 | Polar residues | ||||
Sequence: AAAVAISNNDTAKSSSDGVLSS | ||||||
Compositional bias | 53-76 | Pro residues | ||||
Sequence: PQRPPRPPTPELVKNIPPPPPNGE | ||||||
Compositional bias | 97-113 | Polar residues | ||||
Sequence: TVRQPEESNTAFSVPPL | ||||||
Compositional bias | 847-862 | Basic and acidic residues | ||||
Sequence: TEETTSKDGCPKPKDD |