A0A0K0JBQ6 · A0A0K0JBQ6_BRUMA

Function

function

Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Features

Showing features for binding site, active site.

136450100150200250300350
TypeIDPosition(s)Description
Binding site26-27NADP+ (UniProtKB | ChEBI); ligand shared between two neighboring subunits
Binding site78NADP+ (UniProtKB | ChEBI); ligand shared between two neighboring subunits; in other chain
Binding site132-134NADP+ (UniProtKB | ChEBI); ligand shared between two neighboring subunits; in other chain
Binding site184K+ (UniProtKB | ChEBI)
Binding site186K+ (UniProtKB | ChEBI)
Active site189Thioimidate intermediate
Binding site189K+ (UniProtKB | ChEBI)
Active site191Proton donor/acceptor
Binding site192K+ (UniProtKB | ChEBI)
Binding site222-224GMP (UniProtKB | ChEBI)
Binding site245-246GMP (UniProtKB | ChEBI)
Binding site271-273GMP (UniProtKB | ChEBI)
Binding site272NADP+ (UniProtKB | ChEBI); ligand shared between two neighboring subunits; in other chain
Binding site288-289NADP+ (UniProtKB | ChEBI); ligand shared between two neighboring subunits; in other chain
Binding site289-293GMP (UniProtKB | ChEBI)
Binding site317-320NADP+ (UniProtKB | ChEBI); ligand shared between two neighboring subunits

GO annotations

AspectTerm
Cellular ComponentGMP reductase complex
Molecular FunctionGMP reductase activity
Molecular Functionmetal ion binding
Biological Processpurine nucleobase metabolic process
Biological Processpurine nucleotide metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    GMP reductase
  • EC number
  • Short names
    GMPR
  • Alternative names
    • Guanosine 5'-monophosphate oxidoreductase
      (Guanosine monophosphate reductase
      )

Gene names

    • Name
      bma-gmpr-1
    • ORF names
      Bm3759
      , BM_Bm3759

Organism names

  • Taxonomic identifier
  • Strain
    • FR3
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Spirurina > Spiruromorpha > Filarioidea > Onchocercidae > Brugia

Accessions

  • Primary accession
    A0A0K0JBQ6

Proteomes

Organism-specific databases

Subcellular Location

Interaction

Subunit

Homotetramer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain10-343IMP dehydrogenase/GMP reductase

Sequence similarities

Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    364
  • Mass (Da)
    40,032
  • Last updated
    2015-10-14 v1
  • Checksum
    31E4800A7ACEBC1E
MPRVEYEPKLDFKDVLLRPKRSTLKSRADVDLVREFIFRNSKKKYVGIPVIASNMDTVGTFEVAEVLSKKKLFTFIHKHYSVEQWVEFVSRTDSNQDTMSQIGISSGVSDFDFAKLKEICGLIPELQYICLDVANGYTEMFVDFIRRVREGFPRHTIFAGNVVTGEMIEELILSGVDVVKVGLGPGSVCTTRKKTGVGYPQLSAVLECADAAHGLNGHVVSDGGCTNPGDVAKAFGAGADFVMIGGLFAGHDQCGGDTVVKDGQKYKLFYGMASDTAMKRHEGSVAEYRASEGKTITLPCRGDISDTVQDLLGGLRSACTYTGAKKLKELSKRATFVRVTQQTNEQYTTFEISPSELQKLNIRI

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LN856924
EMBL· GenBank· DDBJ
CTP81075.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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