A0A0K0HG41 · A0A0K0HG41_SALBC

Function

function

An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionD-tyrosyl-tRNA(Tyr) deacylase activity
Molecular FunctionGly-tRNA(Ala) hydrolase activity
Molecular FunctionSer(Gly)-tRNA(Ala) hydrolase activity
Molecular FunctiontRNA binding
Biological ProcessD-amino acid catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    D-aminoacyl-tRNA deacylase
  • EC number
  • Short names
    DTD
  • Alternative names
    • Gly-tRNA(Ala) deacylase
      (EC:3.1.1.-
      ) . EC:3.1.1.- (UniProtKB | ENZYME | Rhea)

Gene names

    • Name
      yihZ
    • Synonyms
      dtd
    • Ordered locus names
      SBG_3545

Organism names

Accessions

  • Primary accession
    A0A0K0HG41

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for motif.

TypeIDPosition(s)Description
Motif137-138Gly-cisPro motif, important for rejection of L-amino acids

Domain

A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.

Sequence similarities

Belongs to the DTD family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    145
  • Mass (Da)
    15,906
  • Last updated
    2015-10-14 v1
  • Checksum
    1751D8F1799E69F4
MIALIQRVTRASVTVEGEVTGEIGPGLLVLLGVEKDDDEQKANRLCERVLGYRIFSDADGKMNLNVQQAGGSVLVVSQFTLAADTERGMRPGFSKGAAPDHAEALYEYFVDRCRQQDMHTQTGRFAADMQVSLVNDGPVTFWLQV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FR877557
EMBL· GenBank· DDBJ
CCC32592.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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