A0A0K0E5I3 · A0A0K0E5I3_STRER
- ProteinAdenylate kinase isoenzyme 1
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids206 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.
Catalytic activity
- AMP + ATP = 2 ADP
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 29-34 | ATP (UniProtKB | ChEBI) | |||
Binding site | 50 | AMP (UniProtKB | ChEBI) | |||
Binding site | 55 | AMP (UniProtKB | ChEBI) | |||
Binding site | 76-78 | AMP (UniProtKB | ChEBI) | |||
Binding site | 106-109 | AMP (UniProtKB | ChEBI) | |||
Binding site | 113 | AMP (UniProtKB | ChEBI) | |||
Binding site | 144 | ATP (UniProtKB | ChEBI) | |||
Binding site | 150 | AMP (UniProtKB | ChEBI) | |||
Binding site | 161 | AMP (UniProtKB | ChEBI) | |||
Binding site | 189 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | (d)CMP kinase activity | |
Molecular Function | adenylate kinase activity | |
Molecular Function | ATP binding | |
Molecular Function | nucleoside diphosphate kinase activity | |
Biological Process | ADP biosynthetic process | |
Biological Process | AMP metabolic process | |
Biological Process | ATP metabolic process | |
Biological Process | nucleoside triphosphate biosynthetic process | |
Biological Process | phosphorylation |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAdenylate kinase isoenzyme 1
- EC number
- Short namesAK 1
- Alternative names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Tylenchina > Panagrolaimomorpha > Strongyloidoidea > Strongyloididae > Strongyloides
Accessions
- Primary accessionA0A0K0E5I3
Proteomes
Subcellular Location
Interaction
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 49-78 | NMPbind | |||
Region | 143-153 | LID | |||
Domain
Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
Sequence similarities
Belongs to the adenylate kinase family. AK1 subfamily.
Family and domain databases
Sequence
- Sequence statusComplete
- Length206
- Mass (Da)22,795
- Last updated2015-10-14 v1
- MD5 ChecksumF8652B271D2C954A0A7AFE07A3DAF426
Keywords
- Technical term