A0A0K0CUR5 · A0A0K0CUR5_ANGCA

Function

function

Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.

Catalytic activity

Cofactor

Fe cation (UniProtKB | Rhea| CHEBI:24875 )

Note: Binds 2 iron ions per subunit.

Pathway

Cofactor biosynthesis; ubiquinone biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site30Fe cation 1 (UniProtKB | ChEBI)
Binding site60Fe cation 1 (UniProtKB | ChEBI)
Binding site60Fe cation 2 (UniProtKB | ChEBI)
Binding site63Fe cation 1 (UniProtKB | ChEBI)
Binding site112Fe cation 2 (UniProtKB | ChEBI)
Binding site148Fe cation 2 (UniProtKB | ChEBI)
Binding site148Fe cation 1 (UniProtKB | ChEBI)
Binding site151Fe cation 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentextrinsic component of mitochondrial inner membrane
Cellular Componentnucleus
Molecular Function3-demethoxyubiquinol 3-hydroxylase activity
Molecular Functionmetal ion binding
Molecular Functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
Biological Processdetermination of adult lifespan
Biological Processregulation of gene expression
Biological Processregulation of reactive oxygen species metabolic process
Biological Processubiquinone biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    5-demethoxyubiquinone hydroxylase, mitochondrial
  • EC number
  • Short names
    DMQ hydroxylase
  • Alternative names
    • Ubiquinone biosynthesis monooxygenase COQ7

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Strongyloidea > Metastrongylidae > Angiostrongylus

Accessions

  • Primary accession
    A0A0K0CUR5

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Component of a multi-subunit COQ enzyme complex.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the COQ7 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    187
  • Mass (Da)
    20,755
  • Last updated
    2015-10-14 v1
  • Checksum
    8A184B9DFD8A6EAA
MNRVFYRAAHSAAARKALLEKVIRVDHAGELGADRIYAGQMAVFQGSSVGSVIKKMWDEEREHLDTMERLAAKHDVPPTIFAPIFSVAAYTVGVASALLGKEGAMACTVAVEELIGRHYNNQLKELMADDPEAHKELLEILTKMRDDELNHHDTGIKYDGLKAPMFEVLKFVIQTGCRGAIYIAERT

Keywords

Genome annotation databases

Similar Proteins

Disclaimer

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