A0A0K0CUR5 · A0A0K0CUR5_ANGCA
- Protein5-demethoxyubiquinone hydroxylase, mitochondrial
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids187 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.
Catalytic activity
- a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + AH2 + O2 = A + a 3-demethylubiquinol + H2O
a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol RHEA-COMP:10859 + CHEBI:17499 + CHEBI:15379 = CHEBI:13193 + a 3-demethylubiquinol RHEA-COMP:10914 + CHEBI:15377
Cofactor
Note: Binds 2 iron ions per subunit.
Pathway
Cofactor biosynthesis; ubiquinone biosynthesis.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 30 | Fe cation 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 60 | Fe cation 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 60 | Fe cation 2 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 63 | Fe cation 1 (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 112 | Fe cation 2 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 148 | Fe cation 2 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 148 | Fe cation 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 151 | Fe cation 2 (UniProtKB | ChEBI) | ||||
Sequence: H |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | extrinsic component of mitochondrial inner membrane | |
Cellular Component | nucleus | |
Molecular Function | 3-demethoxyubiquinol 3-hydroxylase activity | |
Molecular Function | metal ion binding | |
Molecular Function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen | |
Biological Process | determination of adult lifespan | |
Biological Process | regulation of gene expression | |
Biological Process | regulation of reactive oxygen species metabolic process | |
Biological Process | ubiquinone biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name5-demethoxyubiquinone hydroxylase, mitochondrial
- EC number
- Short namesDMQ hydroxylase
- Alternative names
Organism names
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Strongyloidea > Metastrongylidae > Angiostrongylus
Accessions
- Primary accessionA0A0K0CUR5
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Peripheral membrane protein
Keywords
- Cellular component
Interaction
Structure
Sequence
- Sequence statusComplete
- Length187
- Mass (Da)20,755
- Last updated2015-10-14 v1
- Checksum8A184B9DFD8A6EAA
Keywords
- Technical term