A0A0J8YVP1 · A0A0J8YVP1_9GAMM

Function

function

Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Activity regulation

Uridylyltransferase (UTase) activity is inhibited by glutamine, while glutamine activates uridylyl-removing (UR) activity.

GO annotations

AspectTerm
Molecular Function[protein-PII] uridylyltransferase activity
Molecular Functionguanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity
Molecular Functionphosphoric diester hydrolase activity
Biological Processregulation of nitrogen utilization

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Bifunctional uridylyltransferase/uridylyl-removing enzyme
  • Short names
    UTase/UR
  • Alternative names
    • Bifunctional [protein-PII] modification enzyme
    • Bifunctional nitrogen sensor protein

Including 2 domains:

  • Recommended name
    [Protein-PII] uridylyltransferase
  • EC number
  • Short names
    PII uridylyltransferase
    ; UTase
  • Recommended name
    [Protein-PII]-UMP uridylyl-removing enzyme
  • EC number
  • Short names
    UR

Gene names

    • Name
      glnD
    • ORF names
      AI29_14450

Organism names

Accessions

  • Primary accession
    A0A0J8YVP1

Proteomes

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region1-342Uridylyltransferase
Region343-701Uridylyl-removing
Domain461-576HD
Domain702-785ACT
Domain809-883ACT

Domain

Has four distinct domains: an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing.

Sequence similarities

Belongs to the GlnD family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    883
  • Mass (Da)
    101,978
  • Last updated
    2015-10-14 v1
  • Checksum
    6183BDA395B47025
MSVPVPQALTELIHVPDSWQDNQLQRDSIKAALDHFQQRSAEAFDQGVAVDELIAARSHFIDHLLQRLWTYYQLSESTELALVAVGGYGRQELLPLSDIDLLILSRQPLTPVQAQHISELITLLWDVKLEVGQSVRTLEECLTEGLADLTIATNLIESRMLIGDVSLLLELQKNIFSEEFWPSVHFFSAKIKEQTERHLRYHGTSYNLEPDIKSSPGGLRDIHMLQWVAHRHFGATSLDNMVQFGFLTDEERDELKTCQSFLWRLRFALHQTLTRYDNRLLFDRQLSVATRLNYLGEGNTPVEKMMKDYYRVTRRIRELNTMLLQLFDEAILTLPTTERPRPIDDLFRLRGDLIELRDSLSFTQSPETILKMFLVMVRHPEITGIYSATLRQLRLALQQLEKPLCDIAAARPLFLEILGSSGAVSRALMPMHHHGVLAAYLPQWESIVGQMQFDLFHAYTVDEHTMRVLQKLESFGREEVRPQHPLCVEIWQRSPNHLILIIAAIFHDIAKGRGGDHSLLGAEDVHAFAKLHQLNSRDSDLIAWLVEHHLLMSVTAQRRDIQDPEVIRQFSEIMVNERQLKFLTCLTVADICATNESLWNSWKQSLLRELFFATEKQLRRGKDKRPDLRSRVRHNRQQALALLRMNDVDENRLFHLWNRCRADYFLRHTPTQLAWHAQHLLKHRLSEPLVLISPQSARGGTEIFIWSPDRAYLFATVAGELDRRNLSVHDAQIFTNRDGMAMDTFIVLDPEGSPLASDRHASIIQGLTQSLQQEKWIIPKTRRTSSRLRHFTVETRVHYLPGHTDRRTYLELVALDQPGLLAQIGAIFAELDISLHGARISTIGERVEDLFILADNERRGLSKKMREQLRQRLTETLNPTDKI

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JMSP01000067
EMBL· GenBank· DDBJ
KMV73947.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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