A0A0J8U1B4 · A0A0J8U1B4_9MYCO

Function

function

Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.
Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
FMN (UniProtKB | Rhea| CHEBI:58210 )

Note: Binds 1 FMN per subunit.
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 2/5.
Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 3/5.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site281CTP (UniProtKB | ChEBI)
Binding site291CTP (UniProtKB | ChEBI)
Binding site333CTP (UniProtKB | ChEBI)
Binding site351CTP (UniProtKB | ChEBI)
Binding site355CTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentphosphopantothenoylcysteine decarboxylase complex
Molecular FunctionFMN binding
Molecular Functionmetal ion binding
Molecular Functionphosphopantothenate--cysteine ligase activity
Molecular Functionphosphopantothenoylcysteine decarboxylase activity
Biological Processcoenzyme A biosynthetic process
Biological Processpantothenate catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Coenzyme A biosynthesis bifunctional protein CoaBC
  • Alternative names
    • DNA/pantothenate metabolism flavoprotein
    • Phosphopantothenoylcysteine synthetase/decarboxylase
      (PPCS-PPCDC
      )

Including 2 domains:

  • Recommended name
    Phosphopantothenoylcysteine decarboxylase
  • EC number
  • Short names
    PPC decarboxylase
    ; PPC-DC
  • Alternative names
    • CoaC
  • Recommended name
    Phosphopantothenate--cysteine ligase
  • EC number
  • Alternative names
    • CoaB
    • Phosphopantothenoylcysteine synthetase
      (PPC synthetase
      ; PPC-S
      )

Gene names

    • Name
      coaBC
    • ORF names
      ACT17_31165
      , BN970_02827

Organism names

  • Taxonomic identifier
  • Strains
    • D16
    • MLE
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Mycobacteriaceae > Mycolicibacterium

Accessions

  • Primary accession
    A0A0J8U1B4

Proteomes

Family & Domains

Features

Showing features for region, domain.

Type
IDPosition(s)Description
Region1-191Phosphopantothenoylcysteine decarboxylase
Domain5-171Flavoprotein
Domain187-380DNA/pantothenate metabolism flavoprotein C-terminal
Region192-415Phosphopantothenate--cysteine ligase

Sequence similarities

In the C-terminal section; belongs to the PPC synthetase family.
In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    415
  • Mass (Da)
    42,923
  • Last updated
    2015-10-14 v1
  • Checksum
    89B7D8BC95EB924E
MSAGKRIVVGVAGGIAAYKACTLVRQLTEAGHSVRVLPTESALRFVGAATFEALSGNPVHTGVFTDVHEVPHVRIGQEADLVVVAPATADLLARAVAGRADDLLTATLLTARCPVLFAPAMHTEMWFHPATVDNVATLRRRGAVVLEPASGRLTGADSGAGRLPEAEEIVTFAQLLLERGDALAYDLAGVKALVTAGGTREPLDPVRFIGNRSSGKQGYAVARVLAQRGADVTLIAGNTAGLVDPAGVDVVHIGSAAQLRDAVTKYAPESNVLVMAAAVADFRPAQVAAAKIKKGGASEPSSIDLVRNDDVLAGAVRARAEGQLPNMRAIVGFAAETGDANGDVLFHARAKLQRKGCDLLVVNAVGENRAFEVDHNDGWLLSADGAEVALEHGSKTLMATRIVDSIAAFLGKPGG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CTEF01000002
EMBL· GenBank· DDBJ
CQD14106.1
EMBL· GenBank· DDBJ
Genomic DNA
LFOD01000052
EMBL· GenBank· DDBJ
KMV14275.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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