A0A0J8QR40 · A0A0J8QR40_COCIT

Function

function

Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.

Catalytic activity

  • Release of an N-terminal tripeptide from a polypeptide.
    EC:3.4.14.10 (UniProtKB | ENZYME | Rhea)

Cofactor

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Note: Binds 1 Ca2+ ion per subunit.

Features

Showing features for active site, binding site.

159550100150200250300350400450500550
Type
IDPosition(s)Description
Active site290Charge relay system
Active site294Charge relay system
Active site505Charge relay system
Binding site547Ca2+ (UniProtKB | ChEBI)
Binding site548Ca2+ (UniProtKB | ChEBI)
Binding site575Ca2+ (UniProtKB | ChEBI)
Binding site577Ca2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentextracellular region
Molecular Functionmetal ion binding
Molecular Functionserine-type endopeptidase activity
Molecular Functiontripeptidyl-peptidase activity
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    tripeptidyl-peptidase II
  • EC number

Gene names

    • ORF names
      CISG_04401

Organism names

  • Taxonomic identifier
  • Strain
    • RMSCC 3703
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Onygenales > Onygenaceae > Coccidioides

Accessions

  • Primary accession
    A0A0J8QR40

Proteomes

Subcellular Location

Keywords

  • Cellular component

PTM/Processing

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain214-595Peptidase S53

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    595
  • Mass (Da)
    65,330
  • Last updated
    2015-10-14 v1
  • Checksum
    EC9DAC894306CFCC
MAPRPWVDVVQNISVRIWAIRDVILCGLEVVVASPANRFKLAERLSVIPDGWTRRARANPSSTVHLKVSVRAKDPNLLHRSLLEISTPNHPRYGQHMKQHEVRDIVAPHPEASDGIMAWLHEGGIKPENVENRGDWIDFSTNVDTAERLLNTRFYHFEDKSGKVGKIRALEYSLPSSLSKHVRTVQPTTFFGSMERHRSHILRPVRPASESVAANTPSSLRELYNMQDFQVTNKSRNLLGVSGYLEQYARYSDLNAFIERYVPDANGATFSVELYHGGKNDQDSRLDSVEASLDIQYTVGLTYNTSVTYYSGGGRGPLVPDIDQPDPNDNQNEPYMEQLKFFANLSDSRLPTVLSTSYGENEQSVPAEYAKAVCDEFAKLGARGVSVIFSSGDSGVGSGCLTNDGQNRTRFNPIFPAACPYVTSVGGTENTNPESAVYFSSGGFSEIFPRPSYQNGSVDAFLNQLGDKWAEYFNRNGRGFPDVAAQGVDYAVYDHGQVQYVGGTSASAPLIASVISNLNEVRLSQGKPVLGFLNPWLYSKGHQGFTDIVDGAGTGCTGTNGGPRIPGAAWDAVEGWDPVTGFGTPDFKKLMDLLP

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DS268137
EMBL· GenBank· DDBJ
KMU75114.1
EMBL· GenBank· DDBJ
Genomic DNA

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