A0A0J8CLA4 · A0A0J8CLA4_BETVV
- ProteinEukaryotic translation initiation factor 3 subunit A
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids976 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.
GO annotations
all annotations | all molecular function | nucleotide binding | molecular_function | nucleic acid binding | dna binding | chromatin binding | dna-binding transcription factor activity | rna binding | cytoskeletal motor activity | catalytic activity | nuclease activity | signaling receptor binding | structural molecule activity | transporter activity | binding | protein binding | translation factor activity, rna binding | lipid binding | kinase activity | transferase activity | hydrolase activity | oxygen binding | enzyme regulator activity | carbohydrate binding | signaling receptor activity | translation regulator activity | transcription regulator activity | other molecular function | all biological process | carbohydrate metabolic process | generation of precursor metabolites and energy | nucleobase-containing compound metabolic process | dna metabolic process | translation | lipid metabolic process | transport | response to stress | cell cycle | cell communication | signal transduction | cell-cell signaling | multicellular organism development | circadian rhythm | biological_process | metabolic process | catabolic process | biosynthetic process | response to light stimulus | response to external stimulus | tropism | response to biotic stimulus | response to abiotic stimulus | response to endogenous stimulus | embryo development | post-embryonic development | fruit ripening | abscission | pollination | flower development | cellular process | programmed cell death | photosynthesis | cellular component organization | cell growth | protein metabolic process | cellular homeostasis | secondary metabolic process | reproductive process | cell differentiation | protein modification process | growth | epigenetic regulation of gene expression | response to chemical | anatomical structure development | regulation of molecular function | other biological process | all cellular component | cellular_component | extracellular region | cell wall | intracellular anatomical structure | nucleus | nuclear envelope | nucleoplasm | nucleolus | cytoplasm | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | cytosol | ribosome | cytoskeleton | plasma membrane | chloroplast | plastid | thylakoid | membrane | external encapsulating structure | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | eukaryotic 43S preinitiation complex | |
Cellular Component | eukaryotic 48S preinitiation complex | |
Cellular Component | eukaryotic translation initiation factor 3 complex | |
Molecular Function | mRNA binding | |
Molecular Function | translation initiation factor activity | |
Biological Process | formation of cytoplasmic translation initiation complex |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameEukaryotic translation initiation factor 3 subunit A
- Short nameseIF3a
- Alternative names
Gene names
Organism names
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > Caryophyllales > Chenopodiaceae > Betoideae > Beta
Accessions
- Primary accessionA0A0J8CLA4
Proteomes
Genome annotation databases
Subcellular Location
Interaction
Subunit
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.
Structure
Family & Domains
Features
Showing features for coiled coil, domain, region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Coiled coil | 93-120 | |||||
Sequence: MHLSTERAEVARNQAEALEEALDVEDLE | ||||||
Domain | 316-513 | PCI | ||||
Sequence: LQTIASSVVLAALSVPPYDHTRGASHLELENEKERNMRMANLINFNLDPKPESREVLSRSALLLELVSKGVMSCVLPEVKDLYHLLEHEFLPLDLSIKVQPLLNKISKLGGKLASASSVPEVQLSKYVIALEKLATLRLLQQASQVYQTMTIESLSQMIPFFDFSTVEKISVDAVKHKFLTMKVDHMNGAVSFSILDL | ||||||
Region | 589-610 | Disordered | ||||
Sequence: EELKRQQQQKTNEEAEQKRLAS | ||||||
Compositional bias | 803-854 | Basic and acidic residues | ||||
Sequence: RLREEEESRKREEAERKRKEEAERKAKLDEIAERQRQRERELDEKERLRKQQ | ||||||
Region | 803-976 | Disordered | ||||
Sequence: RLREEEESRKREEAERKRKEEAERKAKLDEIAERQRQRERELDEKERLRKQQILAGDPAARSSETTARLQPEAVPVAAPAAAAAAAAVPTPGAPAPGKYVPRHLREKTVEAPISSQAPASESDRWGRREDRPPADKWRSDDRRSFGSGPDDRRSFGSSGSRSTWSSSRVPPRGS | ||||||
Compositional bias | 924-951 | Basic and acidic residues | ||||
Sequence: SDRWGRREDRPPADKWRSDDRRSFGSGP | ||||||
Compositional bias | 953-976 | Polar residues | ||||
Sequence: DRRSFGSSGSRSTWSSSRVPPRGS |
Sequence similarities
Belongs to the eIF-3 subunit A family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length976
- Mass (Da)113,934
- Last updated2015-10-14 v1
- ChecksumDFFFB33F6CC640B4
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 803-854 | Basic and acidic residues | ||||
Sequence: RLREEEESRKREEAERKRKEEAERKAKLDEIAERQRQRERELDEKERLRKQQ | ||||||
Compositional bias | 924-951 | Basic and acidic residues | ||||
Sequence: SDRWGRREDRPPADKWRSDDRRSFGSGP | ||||||
Compositional bias | 953-976 | Polar residues | ||||
Sequence: DRRSFGSSGSRSTWSSSRVPPRGS |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
KQ090068 EMBL· GenBank· DDBJ | KMT14272.1 EMBL· GenBank· DDBJ | Genomic DNA |