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A0A0J6YQF8 · A0A0J6YQF8_COCIT

Function

function

Secreted metalloproteinase that allows assimilation of proteinaceous substrates. Shows high activities on basic nuclear substrates such as histone and protamine. May be involved in virulence.

Catalytic activity

  • Preferential cleavage of bonds with hydrophobic residues in P1'. Also 3-Asn-|-Gln-4 and 8-Gly-|-Ser-9 bonds in insulin B chain.
    EC:3.4.24.39 (UniProtKB | ENZYME | Rhea)

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

135450100150200250300350
Type
IDPosition(s)Description
Binding site305Zn2+ (UniProtKB | ChEBI); catalytic
Active site306
Binding site309Zn2+ (UniProtKB | ChEBI); catalytic
Binding site320Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Cellular Componentextracellular region
Molecular Functionmetal ion binding
Molecular Functionmetalloendopeptidase activity
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Neutral protease 2
  • EC number
  • Alternative names
    • Deuterolysin

Gene names

    • ORF names
      CIRG_09624

Organism names

  • Taxonomic identifier
  • Strain
    • RMSCC 2394
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Onygenales > Onygenaceae > Coccidioides

Accessions

  • Primary accession
    A0A0J6YQF8

Proteomes

Subcellular Location

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-19
ChainPRO_500511993020-354Neutral protease 2

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the peptidase M35 family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    354
  • Mass (Da)
    39,058
  • Last updated
    2015-10-14 v1
  • MD5 Checksum
    A2684825AAC67A40531BDBDF80B2A702
MKLSSILLALAALVSPAFSYAISHLPRSEGGLDIQLTAIGNTRIKAIITNKADRPLKLLRYNNFFDDAPTQKVEIFKDGNAVQFEGIYQHIYMTDLPDEDFISLTPGESIEREVDIATTADLTQGGAFTISSQGLIPFAEVDSNEVTGAMAFHANDLEMDVDGAVAATVEKAIKPVDKRSRLTNSCTGQRRTATVRAIQASAQLSQRSAQVAQNNAQKLREYFKQTDQRTRQLVVNRFTAVARESTVNGGRTTYDCTDRMGHCQPRTIAYTLPAQNHITNCPIFYQMPLLTNRCHGQDQATTVLHEITHNPAIVQPHCLDHGYGYQAVRRLNAQQSLQNADTYSLFANAVHVGC

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DS028099
EMBL· GenBank· DDBJ
KMP09454.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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