A0A0J6FSZ0 · A0A0J6FSZ0_COCPO

Function

function

Proteolytically removes the C-terminal three residues of farnesylated proteins.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.

Catalytic activity

  • Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic side chains and P3' is any C-terminal residue.
    EC:3.4.24.84 (UniProtKB | ENZYME | Rhea)

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site, active site.

145550100150200250300350400450
TypeIDPosition(s)Description
Binding site297Zn2+ (UniProtKB | ChEBI); catalytic
Active site298
Binding site301Zn2+ (UniProtKB | ChEBI); catalytic
Binding site376Zn2+ (UniProtKB | ChEBI); catalytic
Active site380Proton donor

GO annotations

AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Functionmetal ion binding
Molecular Functionmetalloendopeptidase activity
Biological ProcessCAAX-box protein processing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    CAAX prenyl protease
  • EC number

Gene names

    • ORF names
      CPAG_08482

Organism names

  • Taxonomic identifier
  • Strain
    • RMSCC 3488
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Onygenales > Onygenaceae > Coccidioides

Accessions

  • Primary accession
    A0A0J6FSZ0

Proteomes

Organism-specific databases

Subcellular Location

Endoplasmic reticulum membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane123-148Helical
Transmembrane169-189Helical
Transmembrane195-222Helical
Transmembrane310-329Helical

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain40-224CAAX prenyl protease 1 N-terminal
Domain230-430Peptidase M48

Sequence similarities

Belongs to the peptidase M48A family.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    455
  • Mass (Da)
    51,990
  • Last updated
    2015-10-14 v1
  • Checksum
    05E7CD35A5894AF8
MYILQQLARLLDQPFFPWKKIIVGFSLGQYLLEGFLSLRQYRILQQKKPPKVLEGEVSQEVFDKSQAYGRAKAKFGFVSGLYSQIQNLAFIYYDALPKLWAVTGLWLTRYLPERFQGEITHTLVFVFTFNLITTLLSIPVSYYSTFVLEEKFGFNKQTVKLWVSDMLKGQMLGVVLGAPIISAILKIVQKTGTSFFYYLWLFGMFVQLFAITIYPIAILPLFNKLSPLEPGTLKTGVEALAQKLQFPLKELYVIDGSKRSAHSNAYFYGLPWKKHIVIYDTLIEKSEPEEVVAVLSHELGHWSLSHTTKLFGIAQFHMFYIFALFSAFISNKSLYNSFGFHDEYPIMIGFLLFSDALAPMDAIVKLLMNILSRKFEFEADAFAVKLGYSAELARSLLKLQIQNLSTMDADWMYASYHYSHPILPERLGALGWKGGKVTAKSEDSEKPVKAADREL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
DS268113
EMBL· GenBank· DDBJ
KMM72184.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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