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A0A0J5FSW2 · A0A0J5FSW2_9GAMM

Function

function

Catalyzes the reversible phosphorylation of UMP to UDP.

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Activity regulation

Allosterically activated by GTP. Inhibited by UTP.

Pathway

Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site15-18ATP (UniProtKB | ChEBI)
Binding site57UMP (UniProtKB | ChEBI)
Binding site58ATP (UniProtKB | ChEBI)
Binding site62ATP (UniProtKB | ChEBI)
Binding site77UMP (UniProtKB | ChEBI)
Binding site138-145UMP (UniProtKB | ChEBI)
Binding site165ATP (UniProtKB | ChEBI)
Binding site171ATP (UniProtKB | ChEBI)
Binding site174ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionATP binding
Molecular FunctionUMP kinase activity
Biological Process'de novo' CTP biosynthetic process
Biological Processphosphorylation
Biological ProcessUDP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Uridylate kinase
  • EC number
  • Short names
    UK
  • Alternative names
    • Uridine monophosphate kinase
      (UMP kinase
      ; UMPK
      )

Gene names

    • Name
      pyrH
    • ORF names
      AB204_10145

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • MCB
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Morganellaceae > Xenorhabdus

Accessions

  • Primary accession
    A0A0J5FSW2

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homohexamer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain11-219Aspartate/glutamate/uridylate kinase
Region23-28Involved in allosteric activation by GTP

Sequence similarities

Belongs to the UMP kinase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    242
  • Mass (Da)
    26,294
  • Last updated
    2015-10-14 v1
  • MD5 Checksum
    9E431A857C64A4C816DD76A69A344650
MATNAKPVYQRILLKLSGEALQGEEGFGIDARVLDRMAQEIKELVELGIQVGVVIGGGNLFRGAGLAQAGMNRVVGDHMGMLATVMNGLAMRDALHRAYVNARLMSAIPLNGVCDNYSWAEAISLLRHGRVVIFAAGTGNPFFTTDSAACLRGIEIEADVVLKATKVDGVYSADPEKNPEAELYHELAYQEVLERELKVMDLAAFTLARDHNLPIRVFNMNRPGALRRVVMGENEGTLISNN

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LFCV01000061
EMBL· GenBank· DDBJ
KMJ45224.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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