A0A0J3WDH4 · A0A0J3WDH4_ECOLX
- ProteinGMP reductase
- GeneguaC
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids347 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.
Catalytic activity
- IMP + NADP+ + NH4+ = GMP + 2 H+ + NADPH
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 108-131 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: ADFEKTKQILDLNPALNFVCIDVA | ||||||
Binding site | 181 | K+ (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 183 | K+ (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Active site | 186 | Thioimidate intermediate | ||||
Sequence: C | ||||||
Binding site | 216-239 | NADP+ (UniProtKB | ChEBI) | ||||
Sequence: IVSDGGCTTPGDVAKAFGGGADFV |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | GMP reductase complex | |
Molecular Function | GMP reductase activity | |
Molecular Function | metal ion binding | |
Biological Process | purine nucleotide metabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGMP reductase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Escherichia
Accessions
- Primary accessionA0A0J3WDH4
- Secondary accessions
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Subunit
Homotetramer.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 9-336 | IMP dehydrogenase/GMP reductase | ||||
Sequence: LGFKDVLIRPKRSTLKSRSDVELERQFTFKHSGQSWSGVPIIAANMDTVGTFSMASALASFDILTAVHKHYSVEEWQAFINNSSADVLKHVMVSTGTSDADFEKTKQILDLNPALNFVCIDVANGYSEHFVQFVAKAREAWPTKTICAGNVVTGEMCEELILSGADIVKVGIGPGSVCTTRVKTGVGYPQLSAVIECADAAHGLGGMIVSDGGCTTPGDVAKAFGGGADFVMLGGMLAGHEESGGRIVEENGEKFMLFYGMSSESAMKRHVGGVAEYRAAEGKTVKLPLRGPVENTARDILGGLRSACTYVGASRLKELTKRTTFIRV |
Sequence similarities
Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length347
- Mass (Da)37,369
- Last updated2015-10-14 v1
- Checksum898F4AF37FD00441
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AAADNO010000008 EMBL· GenBank· DDBJ | EAB0912922.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AASFZR010000030 EMBL· GenBank· DDBJ | EFB4533050.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AASDTJ010000019 EMBL· GenBank· DDBJ | EFD1621791.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AASOHJ010000014 EMBL· GenBank· DDBJ | EFE8674031.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AASUOH010000005 EMBL· GenBank· DDBJ | EFH0042402.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AATJYL010000006 EMBL· GenBank· DDBJ | EFM1444726.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAVQAW010000009 EMBL· GenBank· DDBJ | EGD0648865.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAVUAX010000002 EMBL· GenBank· DDBJ | EGE2351648.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AAXCWM010000008 EMBL· GenBank· DDBJ | EGO4708156.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DABERK010000003 EMBL· GenBank· DDBJ | HAI5330830.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DABESF010000006 EMBL· GenBank· DDBJ | HAI5418197.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DABGYN010000002 EMBL· GenBank· DDBJ | HAJ0832727.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DABGZR010000005 EMBL· GenBank· DDBJ | HAJ0995425.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DABGKQ010000004 EMBL· GenBank· DDBJ | HAJ5803878.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
DABICV010000005 EMBL· GenBank· DDBJ | HAJ6807715.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JABFNF010000010 EMBL· GenBank· DDBJ | MBA1887166.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
RNLZ01000003 EMBL· GenBank· DDBJ | MGE12499.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WKUE01000003 EMBL· GenBank· DDBJ | MSI67760.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WCEW01000003 EMBL· GenBank· DDBJ | MTE87975.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WTML01000004 EMBL· GenBank· DDBJ | MWK96204.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JABUPU010000013 EMBL· GenBank· DDBJ | NYP85851.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JABUPJ010000011 EMBL· GenBank· DDBJ | NYQ39210.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MOKI01000027 EMBL· GenBank· DDBJ | OJR54373.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MTPS01000255 EMBL· GenBank· DDBJ | ONG33915.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
QEMT01000001 EMBL· GenBank· DDBJ | PWH64692.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP042615 EMBL· GenBank· DDBJ | QED74582.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP057293 EMBL· GenBank· DDBJ | QMF69243.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP057975 EMBL· GenBank· DDBJ | QMP45288.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
RQTU01000003 EMBL· GenBank· DDBJ | RRD77629.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
RRVG01000002 EMBL· GenBank· DDBJ | RRL50915.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UFZA01000001 EMBL· GenBank· DDBJ | STE03136.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UFZL01000003 EMBL· GenBank· DDBJ | STE77239.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UGCU01000001 EMBL· GenBank· DDBJ | STJ13390.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UGED01000013 EMBL· GenBank· DDBJ | STM08193.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UGFC01000006 EMBL· GenBank· DDBJ | STM19719.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UINH01000001 EMBL· GenBank· DDBJ | SVF06580.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
VHKY01000007 EMBL· GenBank· DDBJ | TZE48480.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LR134238 EMBL· GenBank· DDBJ | VED11854.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LR134246 EMBL· GenBank· DDBJ | VED37518.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CAADJZ010000001 EMBL· GenBank· DDBJ | VFT71088.1 EMBL· GenBank· DDBJ | Genomic DNA |