A0A0J3WDH4 · A0A0J3WDH4_ECOLX

  • Protein
    GMP reductase
  • Gene
    guaC
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.

Catalytic activity

Features

Showing features for binding site, active site.

134750100150200250300
TypeIDPosition(s)Description
Binding site108-131NADP+ (UniProtKB | ChEBI)
Binding site181K+ (UniProtKB | ChEBI)
Binding site183K+ (UniProtKB | ChEBI)
Active site186Thioimidate intermediate
Binding site216-239NADP+ (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentGMP reductase complex
Molecular FunctionGMP reductase activity
Molecular Functionmetal ion binding
Biological Processpurine nucleotide metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    GMP reductase
  • EC number
  • Alternative names
    • Guanosine 5'-monophosphate oxidoreductase
      (Guanosine monophosphate reductase
      )

Gene names

    • Name
      guaC
    • ORF names
      B6R31_002532
      , BK383_14230
      , BKL28_001145
      , BXT93_15620
      , C0P57_002304
      , D9D43_02625
      , DD762_00745
      , DL738_02095
      , DU321_03330
      , EF082_11090
      , EIA08_05995
      , F7N46_12935
      , F9B07_03840
      , FEH53_10280
      , FKO60_12690
      , FTV93_13975
      , G4A38_11400
      , G4A47_11630
      , GKF66_02830
      , GQM21_03100
      , HEP34_001012
      , HJQ60_000754
      , HJS37_001689
      , HL563_03055
      , HL601_07370
      , HLX92_13405
      , HLZ39_05135
      , HND12_10025
      , HVW04_10550
      , HVY77_21500
      , IT029_002006
      , NCTC10082_01463
      , NCTC10764_05846
      , NCTC10974_04696
      , NCTC7922_05734
      , NCTC9044_03103
      , NCTC9077_05183
      , NCTC9702_04848
      , NCTC9962_05782
      , SAMEA3472112_00224

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • 347
    • 570
    • 388724
    • ICBEcBL-II-13
    • AMC_487
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Escherichia

Accessions

  • Primary accession
    A0A0J3WDH4
  • Secondary accessions
    • W8T2Y7

Proteomes

Subcellular Location

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain9-336IMP dehydrogenase/GMP reductase

Sequence similarities

Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    347
  • Mass (Da)
    37,369
  • Last updated
    2015-10-14 v1
  • Checksum
    898F4AF37FD00441
MRIEEDLKLGFKDVLIRPKRSTLKSRSDVELERQFTFKHSGQSWSGVPIIAANMDTVGTFSMASALASFDILTAVHKHYSVEEWQAFINNSSADVLKHVMVSTGTSDADFEKTKQILDLNPALNFVCIDVANGYSEHFVQFVAKAREAWPTKTICAGNVVTGEMCEELILSGADIVKVGIGPGSVCTTRVKTGVGYPQLSAVIECADAAHGLGGMIVSDGGCTTPGDVAKAFGGGADFVMLGGMLAGHEESGGRIVEENGEKFMLFYGMSSESAMKRHVGGVAEYRAAEGKTVKLPLRGPVENTARDILGGLRSACTYVGASRLKELTKRTTFIRVLEQENRIFNNL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AAADNO010000008
EMBL· GenBank· DDBJ
EAB0912922.1
EMBL· GenBank· DDBJ
Genomic DNA
AASFZR010000030
EMBL· GenBank· DDBJ
EFB4533050.1
EMBL· GenBank· DDBJ
Genomic DNA
AASDTJ010000019
EMBL· GenBank· DDBJ
EFD1621791.1
EMBL· GenBank· DDBJ
Genomic DNA
AASOHJ010000014
EMBL· GenBank· DDBJ
EFE8674031.1
EMBL· GenBank· DDBJ
Genomic DNA
AASUOH010000005
EMBL· GenBank· DDBJ
EFH0042402.1
EMBL· GenBank· DDBJ
Genomic DNA
AATJYL010000006
EMBL· GenBank· DDBJ
EFM1444726.1
EMBL· GenBank· DDBJ
Genomic DNA
AAVQAW010000009
EMBL· GenBank· DDBJ
EGD0648865.1
EMBL· GenBank· DDBJ
Genomic DNA
AAVUAX010000002
EMBL· GenBank· DDBJ
EGE2351648.1
EMBL· GenBank· DDBJ
Genomic DNA
AAXCWM010000008
EMBL· GenBank· DDBJ
EGO4708156.1
EMBL· GenBank· DDBJ
Genomic DNA
DABERK010000003
EMBL· GenBank· DDBJ
HAI5330830.1
EMBL· GenBank· DDBJ
Genomic DNA
DABESF010000006
EMBL· GenBank· DDBJ
HAI5418197.1
EMBL· GenBank· DDBJ
Genomic DNA
DABGYN010000002
EMBL· GenBank· DDBJ
HAJ0832727.1
EMBL· GenBank· DDBJ
Genomic DNA
DABGZR010000005
EMBL· GenBank· DDBJ
HAJ0995425.1
EMBL· GenBank· DDBJ
Genomic DNA
DABGKQ010000004
EMBL· GenBank· DDBJ
HAJ5803878.1
EMBL· GenBank· DDBJ
Genomic DNA
DABICV010000005
EMBL· GenBank· DDBJ
HAJ6807715.1
EMBL· GenBank· DDBJ
Genomic DNA
JABFNF010000010
EMBL· GenBank· DDBJ
MBA1887166.1
EMBL· GenBank· DDBJ
Genomic DNA
RNLZ01000003
EMBL· GenBank· DDBJ
MGE12499.1
EMBL· GenBank· DDBJ
Genomic DNA
WKUE01000003
EMBL· GenBank· DDBJ
MSI67760.1
EMBL· GenBank· DDBJ
Genomic DNA
WCEW01000003
EMBL· GenBank· DDBJ
MTE87975.1
EMBL· GenBank· DDBJ
Genomic DNA
WTML01000004
EMBL· GenBank· DDBJ
MWK96204.1
EMBL· GenBank· DDBJ
Genomic DNA
JABUPU010000013
EMBL· GenBank· DDBJ
NYP85851.1
EMBL· GenBank· DDBJ
Genomic DNA
JABUPJ010000011
EMBL· GenBank· DDBJ
NYQ39210.1
EMBL· GenBank· DDBJ
Genomic DNA
MOKI01000027
EMBL· GenBank· DDBJ
OJR54373.1
EMBL· GenBank· DDBJ
Genomic DNA
MTPS01000255
EMBL· GenBank· DDBJ
ONG33915.1
EMBL· GenBank· DDBJ
Genomic DNA
QEMT01000001
EMBL· GenBank· DDBJ
PWH64692.1
EMBL· GenBank· DDBJ
Genomic DNA
CP042615
EMBL· GenBank· DDBJ
QED74582.1
EMBL· GenBank· DDBJ
Genomic DNA
CP057293
EMBL· GenBank· DDBJ
QMF69243.1
EMBL· GenBank· DDBJ
Genomic DNA
CP057975
EMBL· GenBank· DDBJ
QMP45288.1
EMBL· GenBank· DDBJ
Genomic DNA
RQTU01000003
EMBL· GenBank· DDBJ
RRD77629.1
EMBL· GenBank· DDBJ
Genomic DNA
RRVG01000002
EMBL· GenBank· DDBJ
RRL50915.1
EMBL· GenBank· DDBJ
Genomic DNA
UFZA01000001
EMBL· GenBank· DDBJ
STE03136.1
EMBL· GenBank· DDBJ
Genomic DNA
UFZL01000003
EMBL· GenBank· DDBJ
STE77239.1
EMBL· GenBank· DDBJ
Genomic DNA
UGCU01000001
EMBL· GenBank· DDBJ
STJ13390.1
EMBL· GenBank· DDBJ
Genomic DNA
UGED01000013
EMBL· GenBank· DDBJ
STM08193.1
EMBL· GenBank· DDBJ
Genomic DNA
UGFC01000006
EMBL· GenBank· DDBJ
STM19719.1
EMBL· GenBank· DDBJ
Genomic DNA
UINH01000001
EMBL· GenBank· DDBJ
SVF06580.1
EMBL· GenBank· DDBJ
Genomic DNA
VHKY01000007
EMBL· GenBank· DDBJ
TZE48480.1
EMBL· GenBank· DDBJ
Genomic DNA
LR134238
EMBL· GenBank· DDBJ
VED11854.1
EMBL· GenBank· DDBJ
Genomic DNA
LR134246
EMBL· GenBank· DDBJ
VED37518.1
EMBL· GenBank· DDBJ
Genomic DNA
CAADJZ010000001
EMBL· GenBank· DDBJ
VFT71088.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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