A0A0J2K8A7 · A0A0J2K8A7_9ENTR

Function

function

Hydrolysis of phosphatidylcholine with phospholipase A2 (EC 3.1.1.4) and phospholipase A1 (EC 3.1.1.32) activities.

Catalytic activity

Cofactor

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Note: Binds 1 Ca2+ ion per monomer. In the dimeric form the Ca2+ is bound by different amino acids with binding of each Ca2+ shared with ligands coming from each monomer. The Ca2+ ion may have a role in catalysis.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site127Ca2+ 1 (UniProtKB | ChEBI); in dimeric form
Active site163Proton acceptor
Active site165Nucleophile
Binding site168Ca2+ 1 (UniProtKB | ChEBI); in dimeric form
Binding site173Ca2+ 1 (UniProtKB | ChEBI); in dimeric form
Binding site205Ca2+ 1 (UniProtKB | ChEBI); in dimeric form

GO annotations

AspectTerm
Cellular Componentcell outer membrane
Molecular Function1-acyl-2-lysophosphatidylserine acylhydrolase activity
Molecular Functioncalcium ion binding
Molecular Functionphosphatidylserine 1-acylhydrolase activity
Molecular Functionphospholipase A1 activity
Molecular Functionphospholipase A2 activity
Biological Processlipid catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phospholipase A1
  • EC number
  • Alternative names
    • Phosphatidylcholine 1-acylhydrolase

Gene names

    • Name
      pldA
    • ORF names
      CWM85_04350
      , CWN49_05655
      , DN619_11950
      , GW952_20405
      , L373_00471
      , N5C89_18310
      , NCTC11685_03840
      , NP224_27985
      , QRZ49_14370

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • MGH 27
    • A10
    • A2
    • GEO_33_Up_A
    • NCTC11685
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Klebsiella/Raoultella group > Klebsiella

Accessions

  • Primary accession
    A0A0J2K8A7

Proteomes

Subcellular Location

Cell outer membrane
; Multi-pass membrane protein
Note: One of the very few enzymes located there.

Keywords

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-20
ChainPRO_501504118721-290Phospholipase A1

Interaction

Subunit

Homodimer; dimerization is reversible, and the dimeric form is the active one.

Family & Domains

Sequence similarities

Belongs to the phospholipase A1 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    290
  • Mass (Da)
    33,018
  • Last updated
    2017-03-15 v1
  • Checksum
    8758F584E711229D
MRISLACLLALVALPAGVLAQDAPVNKQVHDAPVVRGSIIANLLQDHDNPFLLYPYESNYLLYTWTSDLNKEAIRSYDWAENARKDEVKFQLSLAFPLWRGILGENSLLGASYTQKSWWQLSNSKESAPFRETNYEPQLFLGFATDYSFAGWTLRDVEMGYNHDSNGRSDPTSRSWNRLYTRLMAQNGNWLVEVKPWYVIGSTDDNPDITKYMGYYRLKVGYQLGDAILSAQGQYNWNTGYGGAELGVSYPITKHVRVYTQVYSGYGESLIDYNFNQTRVGVGLMLNDLF

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JCNZ01000003
EMBL· GenBank· DDBJ
EWF93906.1
EMBL· GenBank· DDBJ
Genomic DNA
JAOCBF010000025
EMBL· GenBank· DDBJ
MDH0964794.1
EMBL· GenBank· DDBJ
Genomic DNA
JASUWR010000001
EMBL· GenBank· DDBJ
MDL4488313.1
EMBL· GenBank· DDBJ
Genomic DNA
PIET01000054
EMBL· GenBank· DDBJ
PLM67998.1
EMBL· GenBank· DDBJ
Genomic DNA
PIDR01000102
EMBL· GenBank· DDBJ
PLO73461.1
EMBL· GenBank· DDBJ
Genomic DNA
CP048108
EMBL· GenBank· DDBJ
QHS47797.1
EMBL· GenBank· DDBJ
Genomic DNA
QKPB01000019
EMBL· GenBank· DDBJ
RWT45194.1
EMBL· GenBank· DDBJ
Genomic DNA
UGMS01000002
EMBL· GenBank· DDBJ
STW66112.1
EMBL· GenBank· DDBJ
Genomic DNA
CP102103
EMBL· GenBank· DDBJ
UWZ73954.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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