A0A0J2HD54 · A0A0J2HD54_9ENTR

Function

function

Catalyzes the aminotransferase reaction from putrescine to 2-oxoglutarate, leading to glutamate and 4-aminobutanal, which spontaneously cyclizes to form 1-pyrroline. This is the first step in one of two pathways for putrescine degradation, where putrescine is converted into 4-aminobutanoate (gamma-aminobutyrate or GABA) via 4-aminobutanal. Also functions as a cadaverine transaminase in a a L-lysine degradation pathway to succinate that proceeds via cadaverine, glutarate and L-2-hydroxyglutarate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

Pathway

Amine and polyamine degradation; putrescine degradation; 4-aminobutanal from putrescine (transaminase route): step 1/1.
Amino-acid degradation.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site150-151pyridoxal 5'-phosphate (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain
Binding site274pyridoxal 5'-phosphate (UniProtKB | ChEBI); ligand shared between dimeric partners; in other chain
Binding site332pyridoxal 5'-phosphate (UniProtKB | ChEBI); ligand shared between dimeric partners

GO annotations

AspectTerm
Molecular Functiondiamine transaminase activity
Molecular Functionidentical protein binding
Molecular Functionputrescine--2-oxoglutarate transaminase activity
Molecular Functionpyridoxal phosphate binding
Biological ProcessL-lysine catabolic process
Biological Processputrescine catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Putrescine aminotransferase
  • EC number
  • Short names
    PAT
    ; PATase
  • Alternative names
    • Cadaverine transaminase
    • Diamine transaminase
      (EC:2.6.1.29
      ) . EC:2.6.1.29 (UniProtKB | ENZYME | Rhea)
    • Putrescine transaminase
    • Putrescine--2-oxoglutaric acid transaminase

Gene names

    • Name
      patA
    • Synonyms
      ygjG
    • ORF names
      K9I60_28220
      , L373_01128
      , N5C89_10350
      , N7692_20145
      , NCTC11694_05021
      , NCTC9161_01125

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • MGH 27
    • NCTC11694
    • NCTC9161
    • NR1295
    • GD03918
    • GD03999
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Klebsiella/Raoultella group > Klebsiella

Accessions

  • Primary accession
    A0A0J2HD54

Proteomes

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue300N6-(pyridoxal phosphate)lysine

Interaction

Subunit

Homodimer.

Family & Domains

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    459
  • Mass (Da)
    49,507
  • Last updated
    2017-03-15 v1
  • Checksum
    1AECC53DAB06CD92
MNRLPSSASALACSAHALNLIEKRTLDHEEMKSLNQEVREYFKEHVNPGFLAYRKSVTAGGDYGAVEWQAGGLNTLVDTQGQEFIDCLGGFGIFNVGHRNPVVVSAVENQLAKQPLHSQELLDPLRAMLAKTLAALTPGKLKYSFFSNSGTESVEAALKLAKAYQSPRGKFTFVATSGAFHGKSLGALSATAKSTFRKPFMPLLPGFRHVPFGDINAMRTLLSECKKTGDDVAAVILEPIQGEGGVILPPPGYLPAVRKLCDEFGALLILDEVQTGMGRTGKMFACEHENVQPDILCLAKALGGGVMPIGATVATEEVFSVLFDNPFLHTTTFGGNPLACAAALATINVLLTQNLPAQAEQKGDMLLDGFRQLAREYPDLVNDVRGKGMLMAIEFVDNEIGYDFASEMFRQRVLVAGTLNNARTIRIEPPLTLTPEQCEQVLKAARLALAALRVSVEEA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JCNZ01000006
EMBL· GenBank· DDBJ
EWF91872.1
EMBL· GenBank· DDBJ
Genomic DNA
JAIPKU010000004
EMBL· GenBank· DDBJ
MCZ9454545.1
EMBL· GenBank· DDBJ
Genomic DNA
JAOEEU010000024
EMBL· GenBank· DDBJ
MDH0489919.1
EMBL· GenBank· DDBJ
Genomic DNA
JAOCBF010000011
EMBL· GenBank· DDBJ
MDH0963234.1
EMBL· GenBank· DDBJ
Genomic DNA
UGJR01000002
EMBL· GenBank· DDBJ
STR43735.1
EMBL· GenBank· DDBJ
Genomic DNA
UGMW01000003
EMBL· GenBank· DDBJ
STV86443.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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