A0A0J2H4T0 · A0A0J2H4T0_9ENTR

  • Protein
    Undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase
  • Gene
    wecA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55).

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Pathway

Bacterial outer membrane biogenesis; LPS O-antigen biosynthesis.
Bacterial outer membrane biogenesis; enterobacterial common antigen biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site153Mg2+ (UniProtKB | ChEBI)
Binding site217Mg2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular ComponentGram-negative-bacterium-type cell wall
Cellular Componentplasma membrane
Molecular Functionglycosyltransferase activity
Molecular Functionmagnesium ion binding
Molecular Functionmanganese ion binding
Molecular FunctionUDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase activity
Biological Processcell wall macromolecule biosynthetic process
Biological Processcell wall organization
Biological Processenterobacterial common antigen biosynthetic process
Biological ProcessO antigen biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase
  • EC number
  • Alternative names
    • UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase
    • Undecaprenyl-phosphate GlcNAc-1-phosphate transferase

Gene names

    • Name
      wecA
    • ORF names
      CWN49_02455
      , DN619_11770
      , GW952_20575
      , L373_00436
      , N5C89_18490
      , N7692_20930
      , NCTC11694_03890
      , OA42_20735

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • MGH 27
    • CH2
    • A10
    • GEO_33_Up_A
    • NCTC11694
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Klebsiella/Raoultella group > Klebsiella

Accessions

  • Primary accession
    A0A0J2H4T0

Proteomes

Subcellular Location

Cell inner membrane
; Multi-pass membrane protein
Membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane6-24Helical
Transmembrane45-66Helical
Transmembrane72-89Helical
Transmembrane101-126Helical
Transmembrane132-149Helical
Transmembrane161-179Helical
Transmembrane185-202Helical
Transmembrane214-232Helical
Transmembrane244-263Helical
Transmembrane294-315Helical
Transmembrane321-342Helical

Keywords

Family & Domains

Sequence similarities

Belongs to the glycosyltransferase 4 family. WecA subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    364
  • Mass (Da)
    40,573
  • Last updated
    2017-03-15 v1
  • Checksum
    33F89BC71DDC8612
MNLLTAITELISIFLFTTLFIFIARKAAKRVGLVDKPNYRKRHQGLIPLVGGISVFAGICFTFAIADYYIPHARLYLGCAGVLVLVGALDDRFDISVKIRAVIQAAIAVIMMMVGNLHLSSLGFIFGSWELVLGPFGFFLTLFAVWAAINAFNMVDGIDGLLGGLSSVSFAATGIILWFDGQYSLAMWCFAMIAAILPYILLNLGALGRRYKVFMGDAGSTMIGFTIIWILLETTQGKTHPISPVTALWIIAIPLMDMVAIMYRRLRKGMSPFSPDRQHIHHLIMRAGFTSRQAFVLITLAAALLALVGVVAEYTRIVPEWVMLILFLLAFFLYGYCIKRAWKVARMVKRIRRRIRRHSGNNPN

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JCNZ01000003
EMBL· GenBank· DDBJ
EWF93875.1
EMBL· GenBank· DDBJ
Genomic DNA
JSWW01000042
EMBL· GenBank· DDBJ
KKY69664.1
EMBL· GenBank· DDBJ
Genomic DNA
JAOEEU010000026
EMBL· GenBank· DDBJ
MDH0490072.1
EMBL· GenBank· DDBJ
Genomic DNA
JAOCBF010000025
EMBL· GenBank· DDBJ
MDH0964826.1
EMBL· GenBank· DDBJ
Genomic DNA
PIDR01000032
EMBL· GenBank· DDBJ
PLO74857.1
EMBL· GenBank· DDBJ
Genomic DNA
CP048108
EMBL· GenBank· DDBJ
QHS47825.1
EMBL· GenBank· DDBJ
Genomic DNA
QKPB01000019
EMBL· GenBank· DDBJ
RWT45163.1
EMBL· GenBank· DDBJ
Genomic DNA
UGJR01000002
EMBL· GenBank· DDBJ
STR42649.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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