A0A0J2H4T0 · A0A0J2H4T0_9ENTR
- ProteinUndecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase
- GenewecA
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids364 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55).
Catalytic activity
- di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl diphosphate + UMP
Cofactor
Protein has several cofactor binding sites:
Pathway
Bacterial outer membrane biogenesis; LPS O-antigen biosynthesis.
Bacterial outer membrane biogenesis; enterobacterial common antigen biosynthesis.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | Gram-negative-bacterium-type cell wall | |
Cellular Component | plasma membrane | |
Molecular Function | glycosyltransferase activity | |
Molecular Function | magnesium ion binding | |
Molecular Function | manganese ion binding | |
Molecular Function | UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase activity | |
Biological Process | cell wall macromolecule biosynthetic process | |
Biological Process | cell wall organization | |
Biological Process | enterobacterial common antigen biosynthetic process | |
Biological Process | O antigen biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUndecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Klebsiella/Raoultella group > Klebsiella
Accessions
- Primary accessionA0A0J2H4T0
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell inner membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 6-24 | Helical | ||||
Sequence: AITELISIFLFTTLFIFIA | ||||||
Transmembrane | 45-66 | Helical | ||||
Sequence: GLIPLVGGISVFAGICFTFAIA | ||||||
Transmembrane | 72-89 | Helical | ||||
Sequence: HARLYLGCAGVLVLVGAL | ||||||
Transmembrane | 101-126 | Helical | ||||
Sequence: AVIQAAIAVIMMMVGNLHLSSLGFIF | ||||||
Transmembrane | 132-149 | Helical | ||||
Sequence: VLGPFGFFLTLFAVWAAI | ||||||
Transmembrane | 161-179 | Helical | ||||
Sequence: LLGGLSSVSFAATGIILWF | ||||||
Transmembrane | 185-202 | Helical | ||||
Sequence: LAMWCFAMIAAILPYILL | ||||||
Transmembrane | 214-232 | Helical | ||||
Sequence: FMGDAGSTMIGFTIIWILL | ||||||
Transmembrane | 244-263 | Helical | ||||
Sequence: PVTALWIIAIPLMDMVAIMY | ||||||
Transmembrane | 294-315 | Helical | ||||
Sequence: AFVLITLAAALLALVGVVAEYT | ||||||
Transmembrane | 321-342 | Helical | ||||
Sequence: WVMLILFLLAFFLYGYCIKRAW |
Keywords
- Cellular component
Structure
Family & Domains
Sequence similarities
Belongs to the glycosyltransferase 4 family. WecA subfamily.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length364
- Mass (Da)40,573
- Last updated2017-03-15 v1
- Checksum33F89BC71DDC8612
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JCNZ01000003 EMBL· GenBank· DDBJ | EWF93875.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JSWW01000042 EMBL· GenBank· DDBJ | KKY69664.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAOEEU010000026 EMBL· GenBank· DDBJ | MDH0490072.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAOCBF010000025 EMBL· GenBank· DDBJ | MDH0964826.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
PIDR01000032 EMBL· GenBank· DDBJ | PLO74857.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP048108 EMBL· GenBank· DDBJ | QHS47825.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
QKPB01000019 EMBL· GenBank· DDBJ | RWT45163.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UGJR01000002 EMBL· GenBank· DDBJ | STR42649.1 EMBL· GenBank· DDBJ | Genomic DNA |