A0A0J2G780 · A0A0J2G780_KLEPN

  • Protein
    Protein translocase subunit SecA
  • Gene
    secA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

function

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.

Catalytic activity

  • ATP + H2O + cellular proteinSide 1 = ADP + phosphate + cellular proteinSide 2.
    EC:7.4.2.8 (UniProtKB | ENZYME | Rhea)

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Features

Showing features for binding site.

1901100200300400500600700800900
TypeIDPosition(s)Description
Binding site87ATP (UniProtKB | ChEBI)
Binding site105-109ATP (UniProtKB | ChEBI)
Binding site512ATP (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell envelope Sec protein transport complex
Cellular Componentcytosol
Cellular Componentplasma membrane
Molecular FunctionATP binding
Molecular Functionhelicase activity
Molecular Functionmetal ion binding
Biological Processintracellular protein transmembrane transport
Biological Processprotein import
Biological Processprotein targeting
Biological Processprotein transport by the Sec complex

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein translocase subunit SecA
  • EC number

Gene names

    • Name
      secA
    • Synonyms
      azi
      , div
      , secA_1
      , secA_2
    • ORF names
      AI2879V1_3128
      , APT76_01235
      , B5L96_26675
      , B6I68_12035
      , BANRA_04149
      , BANRA_04316
      , BL124_00027890
      , BVZ24_06940
      , DM078_11210
      , DM087_13245
      , DW281_06200
      , EAO17_18300
      , FCH06_005230
      , FNZ01_07185
      , FXN67_14795
      , G4V31_07125
      , GJD55_09345
      , GJJ08_022505
      , GJJ18_04495
      , GJJ21_08585
      , GNF00_08180
      , HV207_22130
      , QIG75_05650
      , SAMEA3499874_03084
      , SAMEA3499901_00809
      , SAMEA3515122_03004
      , SAMEA3538658_00980
      , SAMEA3538828_00849
      , SAMEA3649591_02195
      , SAMEA3649615_03470
      , SAMEA3649733_02941
      , SAMEA3727706_03795

Organism names

  • Taxonomic identifier
  • Organism
  • Strains
    • 11
    • 2429
    • 39383
    • K66-45
    • COL-Kpn30
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Klebsiella/Raoultella group > Klebsiella

Accessions

  • Primary accession
    A0A0J2G780
  • Secondary accessions
    • A0A060VDI1

Proteomes

Subcellular Location

Cell membrane
; Peripheral membrane protein
Cytoplasm
Note: Distribution is 50-50.

Keywords

Expression

Induction

Repressed under conditions of excess protein secretion capacity and derepressed when protein secretion becomes limiting. This is regulated by SecM.

Interaction

Subunit

Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain3-619SecA family profile
Domain89-247Helicase ATP-binding
Domain434-635Helicase C-terminal
Region852-901Disordered

Sequence similarities

Belongs to the SecA family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    901
  • Mass (Da)
    101,961
  • Last updated
    2015-10-14 v1
  • Checksum
    8102491799672B96
MLIKMLTKVFGSRNDRTLRRMRKVVNIINGMEPAMEKLSDDELKAKTAEFRARLEKGETLESLIPEAFAVVREASKRVFGMRHFDVQLLGGMVLNDRCIAEMRTGEGKTLTATLPAYLNALTGKGVHVVTVNDYLAQRDAENNRPLFEFLGMTVGINMSGLPAPAKREAYAADITYGTNNEYGFDYLRDNMAFSPEERVQRKLHYALVDEVDSILIDEARTPLIISGPAEDSSEMYRKVNKIIPHLIRQEKEDSDTFTGEGHFSVDEKARQVNLTERGLVLIEELLVQEGIMDEGESLYSPTNIMLMHHVTAALRAHALFTRDVDYIVKDGEVIIVDEHTGRTMQGRRWSDGLHQAVEAKEGVEIQNENQTLASITFQNYFRLYEKLAGMTGTADTEAFEFSSIYKLDTVVVPTNRPMIRKDMADLVYMTEAEKIQAIIEDIKTRTAAGQPVLVGTISIEKSEVVSRELTKAGIKHNVLNAKFHASEADIVAQAGYPSAVTIATNMAGRGTDIMLGGSWQAEVAALENPTPEQIEKIKADWQVRHDAVLAAGGLHIIGTERHESRRIDNQLRGRAGRQGDAGSSRFYLSMEDALMRIFASDRVSGMMRKLGMKPGEAIEHPWVTKAIANAQRKVESRNFDIRKQLLEYDDVANDQRRAIYTQRNELLDVSDVSETINSIREDVFKATIDAHIPPQSLEEMWDIEGLQERLKNDFDLDLPIKEWLDKEPELHEETLRERILQSAVETYQRKEEVVGAEMMRHFEKGVMLQTLDSLWKEHLAAMDYLRQGIHLRGYAQKDPKQEYKRESFSMFAAMLESLKYEVISTLSKVQVRMPEEVEAMEQQRREEAERLAQMQQLSHQSDDEAAAQDLAAQTGERKVGRNDPCPCGSGKKYKQCHGRLS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CAJNUY030000001
EMBL· GenBank· DDBJ
CAH5396736.1
EMBL· GenBank· DDBJ
Genomic DNA
LNGZ01000101
EMBL· GenBank· DDBJ
KSW89915.1
EMBL· GenBank· DDBJ
Genomic DNA
JARYWG010000004
EMBL· GenBank· DDBJ
MDH8288090.1
EMBL· GenBank· DDBJ
Genomic DNA
WJVZ01000005
EMBL· GenBank· DDBJ
MRK26079.1
EMBL· GenBank· DDBJ
Genomic DNA
WJWF01000003
EMBL· GenBank· DDBJ
MRL34688.1
EMBL· GenBank· DDBJ
Genomic DNA
WMJQ01000004
EMBL· GenBank· DDBJ
MTG00989.1
EMBL· GenBank· DDBJ
Genomic DNA
WNPO01000011
EMBL· GenBank· DDBJ
MUA39824.1
EMBL· GenBank· DDBJ
Genomic DNA
JAAKYD010000005
EMBL· GenBank· DDBJ
NGN71905.1
EMBL· GenBank· DDBJ
Genomic DNA
MSZJ01000004
EMBL· GenBank· DDBJ
OSZ19560.1
EMBL· GenBank· DDBJ
Genomic DNA
NDBK01000112
EMBL· GenBank· DDBJ
OVF65448.1
EMBL· GenBank· DDBJ
Genomic DNA
NCMJ01000062
EMBL· GenBank· DDBJ
PLE27492.1
EMBL· GenBank· DDBJ
Genomic DNA
CP055509
EMBL· GenBank· DDBJ
QLO32617.1
EMBL· GenBank· DDBJ
Genomic DNA
CP063008
EMBL· GenBank· DDBJ
QOU51069.1
EMBL· GenBank· DDBJ
Genomic DNA
QOHW01000006
EMBL· GenBank· DDBJ
RBZ23816.1
EMBL· GenBank· DDBJ
Genomic DNA
QOTY01000007
EMBL· GenBank· DDBJ
RCJ68597.1
EMBL· GenBank· DDBJ
Genomic DNA
QRCD01000005
EMBL· GenBank· DDBJ
RDT90867.1
EMBL· GenBank· DDBJ
Genomic DNA
MPYG04000224
EMBL· GenBank· DDBJ
ROG87199.1
EMBL· GenBank· DDBJ
Genomic DNA
RDAM01000001
EMBL· GenBank· DDBJ
RRF08013.1
EMBL· GenBank· DDBJ
Genomic DNA
UIUC01000006
EMBL· GenBank· DDBJ
SVN64088.1
EMBL· GenBank· DDBJ
Genomic DNA
UIXM01000008
EMBL· GenBank· DDBJ
SVS26252.1
EMBL· GenBank· DDBJ
Genomic DNA
UJTF01000010
EMBL· GenBank· DDBJ
SWV83224.1
EMBL· GenBank· DDBJ
Genomic DNA
UKAW01000007
EMBL· GenBank· DDBJ
SXG16614.1
EMBL· GenBank· DDBJ
Genomic DNA
UKGE01000003
EMBL· GenBank· DDBJ
SXN29816.1
EMBL· GenBank· DDBJ
Genomic DNA
UKUT01000006
EMBL· GenBank· DDBJ
SYH33021.1
EMBL· GenBank· DDBJ
Genomic DNA
UKXO01000003
EMBL· GenBank· DDBJ
SYK76914.1
EMBL· GenBank· DDBJ
Genomic DNA
ULCI01000003
EMBL· GenBank· DDBJ
SYR31533.1
EMBL· GenBank· DDBJ
Genomic DNA
ULET01000009
EMBL· GenBank· DDBJ
SYU74206.1
EMBL· GenBank· DDBJ
Genomic DNA
VKCV01000005
EMBL· GenBank· DDBJ
TRV91689.1
EMBL· GenBank· DDBJ
Genomic DNA
VSSY01000011
EMBL· GenBank· DDBJ
TYL78277.1
EMBL· GenBank· DDBJ
Genomic DNA
SUOY02000004
EMBL· GenBank· DDBJ
TYY86919.1
EMBL· GenBank· DDBJ
Genomic DNA
UWWN01000001
EMBL· GenBank· DDBJ
VCX73276.1
EMBL· GenBank· DDBJ
Genomic DNA
UWWS01000001
EMBL· GenBank· DDBJ
VCX99652.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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