A0A0J2G780 · A0A0J2G780_KLEPN
- ProteinProtein translocase subunit SecA
- GenesecA
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids901 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
Catalytic activity
Cofactor
Features
Showing features for binding site.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cell envelope Sec protein transport complex | |
Cellular Component | cytosol | |
Cellular Component | plasma membrane | |
Molecular Function | ATP binding | |
Molecular Function | helicase activity | |
Molecular Function | metal ion binding | |
Biological Process | intracellular protein transmembrane transport | |
Biological Process | protein import | |
Biological Process | protein targeting | |
Biological Process | protein transport by the Sec complex |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameProtein translocase subunit SecA
- EC number
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Klebsiella/Raoultella group > Klebsiella
Accessions
- Primary accessionA0A0J2G780
- Secondary accessions
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Peripheral membrane protein
Note: Distribution is 50-50.
Keywords
- Cellular component
Expression
Induction
Repressed under conditions of excess protein secretion capacity and derepressed when protein secretion becomes limiting. This is regulated by SecM.
Interaction
Subunit
Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 3-619 | SecA family profile | ||||
Sequence: IKMLTKVFGSRNDRTLRRMRKVVNIINGMEPAMEKLSDDELKAKTAEFRARLEKGETLESLIPEAFAVVREASKRVFGMRHFDVQLLGGMVLNDRCIAEMRTGEGKTLTATLPAYLNALTGKGVHVVTVNDYLAQRDAENNRPLFEFLGMTVGINMSGLPAPAKREAYAADITYGTNNEYGFDYLRDNMAFSPEERVQRKLHYALVDEVDSILIDEARTPLIISGPAEDSSEMYRKVNKIIPHLIRQEKEDSDTFTGEGHFSVDEKARQVNLTERGLVLIEELLVQEGIMDEGESLYSPTNIMLMHHVTAALRAHALFTRDVDYIVKDGEVIIVDEHTGRTMQGRRWSDGLHQAVEAKEGVEIQNENQTLASITFQNYFRLYEKLAGMTGTADTEAFEFSSIYKLDTVVVPTNRPMIRKDMADLVYMTEAEKIQAIIEDIKTRTAAGQPVLVGTISIEKSEVVSRELTKAGIKHNVLNAKFHASEADIVAQAGYPSAVTIATNMAGRGTDIMLGGSWQAEVAALENPTPEQIEKIKADWQVRHDAVLAAGGLHIIGTERHESRRIDNQLRGRAGRQGDAGSSRFYLSMEDALMRIFASDRVSGMMRKLGMKPGEAIE | ||||||
Domain | 89-247 | Helicase ATP-binding | ||||
Sequence: LGGMVLNDRCIAEMRTGEGKTLTATLPAYLNALTGKGVHVVTVNDYLAQRDAENNRPLFEFLGMTVGINMSGLPAPAKREAYAADITYGTNNEYGFDYLRDNMAFSPEERVQRKLHYALVDEVDSILIDEARTPLIISGPAEDSSEMYRKVNKIIPHLI | ||||||
Domain | 434-635 | Helicase C-terminal | ||||
Sequence: KIQAIIEDIKTRTAAGQPVLVGTISIEKSEVVSRELTKAGIKHNVLNAKFHASEADIVAQAGYPSAVTIATNMAGRGTDIMLGGSWQAEVAALENPTPEQIEKIKADWQVRHDAVLAAGGLHIIGTERHESRRIDNQLRGRAGRQGDAGSSRFYLSMEDALMRIFASDRVSGMMRKLGMKPGEAIEHPWVTKAIANAQRKVE | ||||||
Region | 852-901 | Disordered | ||||
Sequence: AQMQQLSHQSDDEAAAQDLAAQTGERKVGRNDPCPCGSGKKYKQCHGRLS |
Sequence similarities
Belongs to the SecA family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length901
- Mass (Da)101,961
- Last updated2015-10-14 v1
- Checksum8102491799672B96
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CAJNUY030000001 EMBL· GenBank· DDBJ | CAH5396736.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
LNGZ01000101 EMBL· GenBank· DDBJ | KSW89915.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JARYWG010000004 EMBL· GenBank· DDBJ | MDH8288090.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WJVZ01000005 EMBL· GenBank· DDBJ | MRK26079.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WJWF01000003 EMBL· GenBank· DDBJ | MRL34688.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WMJQ01000004 EMBL· GenBank· DDBJ | MTG00989.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
WNPO01000011 EMBL· GenBank· DDBJ | MUA39824.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
JAAKYD010000005 EMBL· GenBank· DDBJ | NGN71905.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MSZJ01000004 EMBL· GenBank· DDBJ | OSZ19560.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
NDBK01000112 EMBL· GenBank· DDBJ | OVF65448.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
NCMJ01000062 EMBL· GenBank· DDBJ | PLE27492.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP055509 EMBL· GenBank· DDBJ | QLO32617.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP063008 EMBL· GenBank· DDBJ | QOU51069.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
QOHW01000006 EMBL· GenBank· DDBJ | RBZ23816.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
QOTY01000007 EMBL· GenBank· DDBJ | RCJ68597.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
QRCD01000005 EMBL· GenBank· DDBJ | RDT90867.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
MPYG04000224 EMBL· GenBank· DDBJ | ROG87199.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
RDAM01000001 EMBL· GenBank· DDBJ | RRF08013.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UIUC01000006 EMBL· GenBank· DDBJ | SVN64088.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UIXM01000008 EMBL· GenBank· DDBJ | SVS26252.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UJTF01000010 EMBL· GenBank· DDBJ | SWV83224.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UKAW01000007 EMBL· GenBank· DDBJ | SXG16614.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UKGE01000003 EMBL· GenBank· DDBJ | SXN29816.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UKUT01000006 EMBL· GenBank· DDBJ | SYH33021.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UKXO01000003 EMBL· GenBank· DDBJ | SYK76914.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
ULCI01000003 EMBL· GenBank· DDBJ | SYR31533.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
ULET01000009 EMBL· GenBank· DDBJ | SYU74206.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
VKCV01000005 EMBL· GenBank· DDBJ | TRV91689.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
VSSY01000011 EMBL· GenBank· DDBJ | TYL78277.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
SUOY02000004 EMBL· GenBank· DDBJ | TYY86919.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UWWN01000001 EMBL· GenBank· DDBJ | VCX73276.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
UWWS01000001 EMBL· GenBank· DDBJ | VCX99652.1 EMBL· GenBank· DDBJ | Genomic DNA |