A0A0J1G561 · A0A0J1G561_9FIRM

  • Protein
    Serine hydroxymethyltransferase
  • Gene
    glyA
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

pyridoxal 5'-phosphate (UniProtKB | Rhea| CHEBI:597326 )

Pathway

Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.
One-carbon metabolism; tetrahydrofolate interconversion.

Features

Showing features for binding site, site.

TypeIDPosition(s)Description
Binding site120(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)
Binding site124-126(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)
Site227Plays an important role in substrate specificity
Binding site242(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)
Binding site353-355(6S)-5,6,7,8-tetrahydrofolate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functioncobalt ion binding
Molecular Functionglycine hydroxymethyltransferase activity
Molecular Functionpyridoxal phosphate binding
Molecular Functionserine binding
Molecular Functionzinc ion binding
Biological Processfolic acid metabolic process
Biological Processglycine biosynthetic process from serine
Biological ProcessL-serine catabolic process
Biological Processtetrahydrofolate interconversion

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Serine hydroxymethyltransferase
  • EC number
  • Short names
    SHMT
    ; Serine methylase

Gene names

    • Name
      glyA
    • ORF names
      RHS_3750

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • RHS
  • Taxonomic lineage
    Bacteria > Bacillota > Clostridia > Lachnospirales > Lachnospiraceae > Robinsoniella

Accessions

  • Primary accession
    A0A0J1G561

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue228N6-(pyridoxal phosphate)lysine

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain8-384Serine hydroxymethyltransferase-like

Sequence similarities

Belongs to the SHMT family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    412
  • Mass (Da)
    44,399
  • Last updated
    2015-10-14 v1
  • Checksum
    DB506EAE095FF059
MYSLDEVRSVDPEVASAIEAEQDRQNSHIELIASENWVSKAVMAAMGSPLTNKYAEGYPGKRYYGGCECVDVVETLAIERAKEIFGCTYANVQPHSGAQANMAVFFAMLKPGDTVMGMNLAHGGHLTHGSPANMSGAYFNAVPYGVNDEGFIDYEEVRRIALESKPKMIVAGASAYARTIDFKKFREIADEVNAYLMVDMAHIAGLVAAGVHPSPIPYADVVTTTTHKTLRGPRGGLILCSEETAKKFNFNKAVFPGIQGGPLMHVIAAKAVCFKEALSDEYKEYQKNIVKNAQALSKGLMSRGIKIVSGGTDNHLMLVDLSVLGQTGKAVEKILDSVNITCNKNTIPNDPQSAFVTSGVRLGTPAVTARGMVEADMDIIAEAIAMMLQSPEENHDKALALVQSLTEKYPLS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JNGB01000042
EMBL· GenBank· DDBJ
KLU70428.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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