A0A0J1FYU6 · A0A0J1FYU6_9FIRM

  • Protein
    Uracil phosphoribosyltransferase
  • Gene
    upp
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit. The magnesium is bound as Mg-PRPP.

Activity regulation

Allosterically activated by GTP.

Pathway

Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site735-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site985-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site125-1335-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site188uracil (UniProtKB | ChEBI)
Binding site193-195uracil (UniProtKB | ChEBI)
Binding site1945-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular FunctionGTP binding
Molecular Functionmagnesium ion binding
Molecular Functionuracil phosphoribosyltransferase activity
Biological ProcessUMP salvage
Biological Processuracil salvage

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Uracil phosphoribosyltransferase
  • EC number
  • Alternative names
    • UMP pyrophosphorylase
    • UPRTase

Gene names

    • Name
      upp
    • ORF names
      RHS_5958

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • RHS
  • Taxonomic lineage
    Bacteria > Bacillota > Clostridia > Lachnospirales > Lachnospiraceae > Robinsoniella

Accessions

  • Primary accession
    A0A0J1FYU6

Proteomes

Family & Domains

Sequence similarities

Belongs to the UPRTase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    203
  • Mass (Da)
    22,418
  • Last updated
    2015-10-14 v1
  • Checksum
    BA34321E191295B4
MDHPLIQHKIGIIRRKEVGSKDFRQMISEIAMLMCYEATRDLKLVDVDIETPICPMTAKELQGKKLAVVPILRAGLGMVDGMLAMIPAAKVGHIGLYRDPETLEPVEYYSKLPADSWDREVFVVDPMLATGGSSSAAINLLKEKGVKNIRFMCIIAAPEGVKRMQTEHPDVDIYIGALDERLNDHGYIVPGLGDAGDRIFGTK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
JNGB01000211
EMBL· GenBank· DDBJ
KLU68218.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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