A0A0J1D6W8 · A0A0J1D6W8_9BURK

  • Protein
    DNA-(Apurinic or apyrimidinic site) lyase
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Probably binds two magnesium or manganese ions per subunit.

Features

Showing features for binding site, active site, site.

125620406080100120140160180200220240
TypeIDPosition(s)Description
Binding site8Mg2+ 1 (UniProtKB | ChEBI)
Binding site36Mg2+ 1 (UniProtKB | ChEBI)
Active site109
Active site149Proton donor/acceptor
Binding site149Mg2+ 1 (UniProtKB | ChEBI)
Binding site151Mg2+ 1 (UniProtKB | ChEBI)
Site151Transition state stabilizer
Site221Important for catalytic activity
Binding site246Mg2+ 1 (UniProtKB | ChEBI)
Active site247Proton acceptor
Binding site247Mg2+ 1 (UniProtKB | ChEBI)
Site247Interaction with DNA substrate

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Molecular FunctionDNA binding
Molecular FunctionDNA-(apurinic or apyrimidinic site) endonuclease activity
Molecular Functiondouble-stranded DNA 3'-5' DNA exonuclease activity
Molecular Functionendonuclease activity
Molecular Functionlyase activity
Molecular Functionmetal ion binding
Molecular Functionphosphoric diester hydrolase activity
Biological Processbase-excision repair

Keywords

Names & Taxonomy

Protein names

  • Submitted names
    • DNA-(Apurinic or apyrimidinic site) lyase

Gene names

    • ORF names
      AB595_21555

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • WF1
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Betaproteobacteria > Burkholderiales > Oxalobacteraceae > Telluria group > Massilia

Accessions

  • Primary accession
    A0A0J1D6W8

Proteomes

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain6-247Endonuclease/exonuclease/phosphatase

Sequence similarities

Belongs to the DNA repair enzymes AP/ExoA family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    256
  • Mass (Da)
    29,019
  • Last updated
    2015-10-14 v1
  • Checksum
    19EF07570B79074A
MPRIISANLNGIRSAHKKGFFNWLATQNADFICVQELKAQQADMTEEFLAPHGYHGHFHYAEKKGYSGTGVYSRSKPDAVRTGFGCVEFDNEGRYTRCDVGALTVISVYCPSGSSSPERQEAKFRFMDVFLPHLQELKAEGREVVICGDWNIAHKEIDLKNWKSNQKNSGFLPEERAWMTRLFDELGLVDVHRAVAPEAADYTWWSNRGQAYAKNVGWRIDYHVATPGIAARAHAVSIYKDERFSDHAPLIIDYAL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LELH02000034
EMBL· GenBank· DDBJ
KLU34844.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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