A0A0H5S397 · A0A0H5S397_BRUMA

Function

function

Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.

Catalytic activity

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentuniplex complex
Molecular Functioncalcium channel activity
Molecular Functionidentical protein binding
Molecular Functionuniporter activity
Biological Processcalcium import into the mitochondrion
Biological Processmitochondrial calcium ion homeostasis
Biological Processprotein homooligomerization
Biological Processregulation of reactive oxygen species biosynthetic process
Biological Processregulation of wound healing

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Calcium uniporter protein

Gene names

    • Name
      Bma-mcu-1
    • ORF names
      BM_Bm4745

Organism names

  • Taxonomic identifier
  • Strain
    • FR3
  • Taxonomic lineage
    Eukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Spirurina > Spiruromorpha > Filarioidea > Onchocercidae > Brugia

Accessions

  • Primary accession
    A0A0H5S397

Proteomes

Subcellular Location

Mitochondrion inner membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane215-234Helical
Transmembrane246-264Helical

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain91-300Calcium uniporter protein C-terminal

Domain

The selectivity filter, in which calcium ions are arranged in single file, is composed of two acidic rings separated by one helical turn along the central axis of the channel pore.

Sequence similarities

Belongs to the MCU (TC 1.A.77) family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    347
  • Mass (Da)
    40,613
  • Last updated
    2015-10-14 v1
  • Checksum
    1BE8D3CF29BCA063
MRCRWYSITGLLQQRQQHLQIQLSTCYINLNNMHHLRRCSNDTTRGNLHIWCQSGLPLLEVPLPSRREICQFTLKPISDTVSRFCKNIECEDKGIEIVYVYSTSGNRIAGSTLLKHLLLRGNFRLRINDFIYTVEVPSSKDVIANIMADGDVMQKFDGLRSTIAPLYSIMNVEVYKAFQERLLIEEYENVKAELKPLIQAKFKFDEFCRKRAQRILWLTLAAMGFQAGFLARLTWWDYSWDVMEPITYFATHATLIASFAYYLYTNQYYNHNDHKKRAISLYFHKKAAKSNFDISRFNELQNVASSIKHDLKKLRDPLYQHLPTARLASLLQESGKVQPRSFTKERS

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A5S6PN63A0A5S6PN63_BRUMABma-mcu-1268

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LN856618
EMBL· GenBank· DDBJ
CRZ22680.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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