A0A0H5RKL3 · A0A0H5RKL3_9EUKA

  • Protein
    Pentafunctional AROM polypeptide
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    5/5

Function

function

The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions per subunit.

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.
Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.
Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.
Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.
Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function3-dehydroquinate dehydratase activity
Molecular Function3-dehydroquinate synthase activity
Molecular Function3-phosphoshikimate 1-carboxyvinyltransferase activity
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Molecular Functionshikimate 3-dehydrogenase (NADP+) activity
Molecular Functionshikimate kinase activity
Biological Processamino acid biosynthetic process
Biological Processaromatic amino acid family biosynthetic process
Biological Processchorismate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Pentafunctional AROM polypeptide

Including 5 domains:

  • Recommended name
    3-dehydroquinate synthase
  • EC number
  • Short names
    DHQS
  • Recommended name
    3-phosphoshikimate 1-carboxyvinyltransferase
  • EC number
  • Recommended name
    Shikimate kinase
  • EC number
  • Short names
    SK
  • Recommended name
    3-dehydroquinate dehydratase
  • EC number
  • Short names
    3-dehydroquinase
  • Recommended name
    Shikimate dehydrogenase
  • EC number

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Sar > Rhizaria > Endomyxa > Phytomyxea > Plasmodiophorida > Plasmodiophoridae > Spongospora

Accessions

  • Primary accession
    A0A0H5RKL3

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain82-3373-dehydroquinate synthase
Domain378-801Enolpyruvate transferase
Domain1241-1322Shikimate dehydrogenase substrate binding N-terminal
Domain1477-1502SDH C-terminal

Sequence similarities

Belongs to the EPSP synthase family.
In the 2nd section; belongs to the EPSP synthase family.
In the 3rd section; belongs to the shikimate kinase family.
In the 4th section; belongs to the type-I 3-dehydroquinase family.
In the C-terminal section; belongs to the shikimate dehydrogenase family.
In the N-terminal section; belongs to the dehydroquinate synthase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,516
  • Mass (Da)
    165,207
  • Last updated
    2015-10-14 v1
  • Checksum
    24FB7A6A5AFA0A48
MMMWSTDLLSYRIHVAPGILLNQNIVSLVTSAIQESNATATPSLVLIVDNAIPRLLPSLIGTLCSLLRTKYTVLLNLLDQEPGGELLKTRKMKACLEDYLLSNSCGRDTVLIGLGGGALGDLVGFVAATFMRGIPYIHIPTTLLSMVDSSIGGKTAINTDFGKNLLGAFYQPIAVFCDLDFLTVLPSRHISNGLAEIIKCGMIADRELFEYCADNAHLITSDRDQEALMHIICSSIAIKARIVSEDSHERGMRAILNFGHSIGHAIERILSPELLHGECVAIGMVYEAMISRSLGFCRSDVILRLCSCLKQYQLPVLMPSSLNHDDILAKMSSDKKNLGLRKRIVLISGVGSVRDDPWTTEVEDDRILIAIGRTISVSPTAQVQGIISVPGSKSISNRVLLLAALSNSKVTISGMLYSEDTEVMIKSLRALGVSINIDGNSNIHVQGNSGKFHAPSEPLFLANAGTASRFLTSVAALLPEGQDCIISGCQRMHDRPINDLVDVLRSCGVEVEYIGLRKDCLPIRVCGGGLKGGNLTLKGSISSQFVSSILMVAPFASNDINLTISGDKVVSRPYIDMTVALMSQFGVQVVCPNLKTFEIKKGQQYKCQDLINVEGDASSASYPLAIAAITRGKVTVSNVGQLSLQGDSQFCQVLQSMGCEVEQSPTTTTVKGPPDGKLLQAVDIDLNSMTDTFMTLAACAAVASGRSFIRNIDNQRVKECNRIQATVSELTKIGIKAGELSDGIWIEGDPLYSGPRAPTAIDCHSDHRIAMMFATLSCRFSNIIISDKNCVGKTYPEFWDDIGTSLHVNMSPAVVPTPSLPTIGCQTPFVLTGMRGCGKSTLGRICSKLLGLRFIDMDAEFVAYTKCSITNYVAEFGWDDFRGVELSLLKDKLRTRNCLIATGGGIVESSEAIALLRSSCSIEIRRDIRDIISKESHLKDRCAPDEPISATWERRRKLYEAASVYEFPISYGDWNWETLSRRLFYLLSRLRSPPISTPLSTSFFVTLTFEDLEEVASVDILRIAEQCDAVEFRVDLLKSYNHDFVRKQWAILRRILGPLPIIFTVRSQSQCGNAPDSPDQLVALLLLGARLAADYVDVESHLSDDHRRQILSIVRSSFCSRIIGSYHSRHNGRGSLSHLFSAAELNGTANIVKVAISATDPLDACRLTLAAETYRKHHPGMPCIALAMGSAGRLSRVMNTFLSPVTHPLLPVAGATGQMTVEEITTLRLSLGLIRPQRFYLFGYPIDRSPSSAMHNAAFTHLRLPHQYSNFSSELISSELRNCIKDHDFGGGSVTIPLKEKIHSLVDRVTDVAKKIGAINTLFRDPENPSALVGDNTDWIGIVRALETVNMELLPETAALVLGAGGTAKAAIFGLCSMGFDSSNVFVYNRTTERARVLSEEFGCCVVSSLDDLPTVNFSVIINTIPWASSFHIPDGHPIFKMSPFAFLDLNYVPGGTRLSRQAAVKGWPVIGGDLVLLYQGIAAFRLWSGYKAPEAIMAKAIASFQEETDEGRQGS

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
HACM01008832
EMBL· GenBank· DDBJ
CRZ09274.1
EMBL· GenBank· DDBJ
Transcribed RNA

Similar Proteins

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