A0A0H5R8A3 · A0A0H5R8A3_9EUKA

  • Protein
    Double-strand break repair protein
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Core component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The MRN complex is involved in the repair of DNA double-strand breaks (DSBs) via homologous recombination (HR), an error-free mechanism which primarily occurs during S and G2 phases. The complex 1 mediates the end resection of damaged DNA, which generates proper single-stranded DNA, a key initial steps in HR, and is 2 required for the recruitment of other repair factors and efficient activation of ATM and ATR upon DNA damage. Within the MRN complex, MRE11 possesses both single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. MRE11 first endonucleolytically cleaves the 5' strand at DNA DSB ends to prevent non-homologous end joining (NHEJ) and licence HR. It then generates a single-stranded DNA gap via 3' to 5' exonucleolytic degradation, which is required for single-strand invasion and recombination.

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Features

Showing features for active site.

159550100150200250300350400450500550
TypeIDPosition(s)Description
Active site129Proton donor

GO annotations

AspectTerm
Cellular ComponentMre11 complex
Cellular Componentsite of double-strand break
Molecular Function3'-5'-DNA exonuclease activity
Molecular Functionmanganese ion binding
Molecular Functionsingle-stranded DNA endodeoxyribonuclease activity
Biological Processdouble-strand break repair via homologous recombination
Biological Processdouble-strand break repair via nonhomologous end joining
Biological Processmeiotic DNA double-strand break formation
Biological Processmitochondrial double-strand break repair via homologous recombination
Biological Processmitotic G2 DNA damage checkpoint signaling
Biological Processtelomere maintenance

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Double-strand break repair protein

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Sar > Rhizaria > Endomyxa > Phytomyxea > Plasmodiophorida > Plasmodiophoridae > Spongospora

Accessions

  • Primary accession
    A0A0H5R8A3

Subcellular Location

Keywords

Family & Domains

Features

Showing features for domain, region, compositional bias.

Type
IDPosition(s)Description
Domain296-464Mre11 DNA-binding
Region505-526Disordered
Region539-595Disordered
Compositional bias557-588Polar residues

Sequence similarities

Belongs to the MRE11/RAD32 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    595
  • Mass (Da)
    66,607
  • Last updated
    2015-10-14 v1
  • Checksum
    4D8875DD6AFBC751
MSSGSLDISPDADTFRILVATDNHLGCEEQDPIRGNDAMRTFEEILVIAKTANVDFILLGGDLFHQNKPSRQCLFDTMQLLRKHCLGDRPISFEMLSDPSTVFHARQCCNYEDPNINISLPIFAIHGNHDDPSGSGGHAALDILDSANFLNYFGRVENISEFCVNPILLRKGTTQLALYGLGSIRDERLHRTLVSKKVSWARPNQDPDQWFNLLVLHQNRTRHSLVYKNCIPESLLPNFLDLVVWAHEHECRIELEESAEGRFWVTQPGSSAATSLCAAETVKKHVGLVEVRGNNVRLTPIPLQSPRPFIMEDIVLEDFARDLPNRSDTVATTSFLHARISSCIARATVEFPRPAGIEVGASEWLPLIRIRVNCQGYQPPNIHRFGQEFIGRVANPDGLIQIMRKQNTGGSRRTKVDRLVLEVDEDGTENRTKIEDLVKDHLSTGNKALGICSELDLADVLERFVSKGDGRAIEEYTLSRLSSVQAQLKAADNVSSDNIEELARNSTQAYRDQQADENTREEQRLQQERDRLQALLNAEDDKGSESEMMGDDEVTQPAPAQRSSTTTKRKASAVLNLSQPAASGQNRSRPRSRRQ

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias557-588Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
HACM01009921
EMBL· GenBank· DDBJ
CRZ10363.1
EMBL· GenBank· DDBJ
Transcribed RNA

Similar Proteins

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