A0A0H5CC70 · A0A0H5CC70_9PSEU

Function

function

Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Pathway

Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 1/4.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site53-57GTP (UniProtKB | ChEBI)
Binding site58Zn2+ (UniProtKB | ChEBI); catalytic
Binding site69Zn2+ (UniProtKB | ChEBI); catalytic
Binding site71Zn2+ (UniProtKB | ChEBI); catalytic
Binding site74GTP (UniProtKB | ChEBI)
Binding site97-99GTP (UniProtKB | ChEBI)
Binding site120GTP (UniProtKB | ChEBI)
Active site132Proton acceptor
Active site134Nucleophile
Binding site155GTP (UniProtKB | ChEBI)
Binding site160GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionGTP binding
Molecular FunctionGTP cyclohydrolase II activity
Molecular Functionlyase activity
Molecular Functionzinc ion binding
Biological Processriboflavin biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    GTP cyclohydrolase-2
  • EC number
  • Alternative names
    • GTP cyclohydrolase II

Gene names

    • Name
      ribA

Organism names

  • Taxonomic identifier
  • Strain
    • L-07
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Pseudonocardiales > Pseudonocardiaceae

Accessions

  • Primary accession
    A0A0H5CC70

Proteomes

Subcellular Location

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain12-176GTP cyclohydrolase II

Sequence similarities

Belongs to the GTP cyclohydrolase II family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    214
  • Mass (Da)
    23,504
  • Last updated
    2015-10-14 v1
  • Checksum
    953696DEB2ACE5A1
MHEQHVINGDDVAESNLVTRRGTFRAVAFRLAGHEHMAMVYGKVRLRERVLVRVHSECMTGDIFGAMRCECGEQLNAALDAIVSEGSGVLIYLRGHEGRGIGLVAKVRTHVLQDEQGLDTLDSATSLGLPVDVRDYTPAATVLRHLGVRSVRLMSNNPDKVDALESQGVPVVDRVPLLVRATDHNIGYLTAKRDRLGHDLPQVDLFDLPRVADS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LN850107
EMBL· GenBank· DDBJ
CRK55064.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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