A0A0H5CC70 · A0A0H5CC70_9PSEU

Function

function

Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Pathway

Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 1/4.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site53-57GTP (UniProtKB | ChEBI)
Binding site58Zn2+ (UniProtKB | ChEBI); catalytic
Binding site69Zn2+ (UniProtKB | ChEBI); catalytic
Binding site71Zn2+ (UniProtKB | ChEBI); catalytic
Binding site74GTP (UniProtKB | ChEBI)
Binding site97-99GTP (UniProtKB | ChEBI)
Binding site120GTP (UniProtKB | ChEBI)
Active site132Proton acceptor
Active site134Nucleophile
Binding site155GTP (UniProtKB | ChEBI)
Binding site160GTP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionGTP binding
Molecular FunctionGTP cyclohydrolase II activity
Molecular Functionlyase activity
Molecular Functionzinc ion binding
Biological Processriboflavin biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    GTP cyclohydrolase-2
  • EC number
  • Alternative names
    • GTP cyclohydrolase II

Gene names

    • Name
      ribA

Organism names

  • Taxonomic identifier
  • Strain
    • L-07
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Pseudonocardiales > Pseudonocardiaceae

Accessions

  • Primary accession
    A0A0H5CC70

Proteomes

Subcellular Location

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain12-176GTP cyclohydrolase II

Sequence similarities

Belongs to the GTP cyclohydrolase II family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    214
  • Mass (Da)
    23,504
  • Last updated
    2015-10-14 v1
  • Checksum
    953696DEB2ACE5A1
MHEQHVINGDDVAESNLVTRRGTFRAVAFRLAGHEHMAMVYGKVRLRERVLVRVHSECMTGDIFGAMRCECGEQLNAALDAIVSEGSGVLIYLRGHEGRGIGLVAKVRTHVLQDEQGLDTLDSATSLGLPVDVRDYTPAATVLRHLGVRSVRLMSNNPDKVDALESQGVPVVDRVPLLVRATDHNIGYLTAKRDRLGHDLPQVDLFDLPRVADS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LN850107
EMBL· GenBank· DDBJ
CRK55064.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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