A0A0H5BP58 · A0A0H5BP58_BLAVI

Function

function

Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Features

Showing features for binding site.

165050100150200250300350400450500550600650
TypeIDPosition(s)Description
Binding site190-193CoA (UniProtKB | ChEBI)
Binding site308CoA (UniProtKB | ChEBI)
Binding site332CoA (UniProtKB | ChEBI)
Binding site384-386ATP (UniProtKB | ChEBI)
Binding site408-413ATP (UniProtKB | ChEBI)
Binding site497ATP (UniProtKB | ChEBI)
Binding site512ATP (UniProtKB | ChEBI)
Binding site520CoA (UniProtKB | ChEBI)
Binding site523ATP (UniProtKB | ChEBI)
Binding site534Mg2+ (UniProtKB | ChEBI)
Binding site536Mg2+ (UniProtKB | ChEBI)
Binding site539Mg2+ (UniProtKB | ChEBI)
Binding site581CoA (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionacetate-CoA ligase activity
Molecular FunctionAMP binding
Molecular FunctionATP binding
Molecular Functionmetal ion binding
Biological Processacetyl-CoA biosynthetic process from acetate

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Acetyl-coenzyme A synthetase
  • EC number
  • Short names
    AcCoA synthetase
    ; Acs
  • Alternative names
    • Acetate--CoA ligase
    • Acyl-activating enzyme

Gene names

    • Name
      acsA_4
    • Synonyms
      acsA
    • ORF names
      BV133_1195
      , BVIRIDIS_29060

Organism names

Accessions

  • Primary accession
    A0A0H5BP58

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue606N6-acetyllysine

Post-translational modification

Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain23-80Acetyl-coenzyme A synthetase N-terminal
Domain82-465AMP-dependent synthetase/ligase
Domain528-606AMP-binding enzyme C-terminal

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    650
  • Mass (Da)
    71,851
  • Last updated
    2015-10-14 v1
  • Checksum
    C09C92745FD2F2DE
MSEKTYDVPAEWSSRAYVDEAKYREIYAASVKDPVAFWGEHGKRIHWFAPYTKVKNTSYDPHNVSIKWYEDGLTNVAYNCVDRHLATRGDQVAIIWEGDNPAEDKKITYRELYEEVCRFANVLKSRGVKKGDRVTLYLPMIPEAAYAMLACARIGAIHSVVFGGFSPDSLAGRIEDAGSTVIVTADEGLRGGRKVPLKLNTDAACDRAGGVESVIVVRRTGANVPMRSGRDVYYDEIAKNMPAECAVAEMNAEDPLFILYTSGSTGKPKGVLHTTGGYLVYAAMTHQYVFDYHDGDIYWCTADVGWVTGHSYIVYGPLANGATTLMFEGVPNYPTISRFWEVIDKHKVNIFYTAPTAIRSLMQAGEAPVTKTSRASLRLLGSVGEPINPEAWEWYHRVVGDHRCPIVDTWWQTETGGILITPLPGAIKLKPGSATLPFFGVVPEVVDANGQVLDGVCEGNLVLSDSWPGQMRTVYGDHERFVQTYFSTYAGKYFTGDGCRRDADGFYWITGRVDDVINVSGHRMGTAEVESALVAHPKVSEAAVVGYPHDIKGQGIYAYVTLMSDIEPSEELRKELVNWVRKEIGPIAQPDLIQFAPSLPKTRSGKIMRRILRKIAEDEFGNLGDTSTLADPGVVEDLIGNRQNRRGVAA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP014854
EMBL· GenBank· DDBJ
BAR98788.1
EMBL· GenBank· DDBJ
Genomic DNA
LN907867
EMBL· GenBank· DDBJ
CUU43878.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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