A0A0H3WMK7 · A0A0H3WMK7_CTEID

Function

Catalytic activity

Features

Showing features for binding site, active site, site.

1976100200300400500600700800900
TypeIDPosition(s)Description
Binding site562Mg2+ (UniProtKB | ChEBI)
Binding site589-597ATP (UniProtKB | ChEBI)
Binding site590-597ATP (UniProtKB | ChEBI)
Binding site617ATP (UniProtKB | ChEBI)
Binding site665-671ATP (UniProtKB | ChEBI)
Active site781Proton acceptor
Binding site785ATP (UniProtKB | ChEBI)
Binding site786Mg2+ (UniProtKB | ChEBI)
Binding site799Mg2+ (UniProtKB | ChEBI)
Site928Important for interaction with phosphotyrosine-binding proteins

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentCSF1-CSF1R complex
Cellular Componentplasma membrane
Cellular Componentreceptor complex
Molecular FunctionATP binding
Molecular Functioncytokine binding
Molecular Functiongrowth factor binding
Molecular Functionmacrophage colony-stimulating factor receptor activity
Molecular Functionmetal ion binding
Biological Processcell surface receptor protein tyrosine kinase signaling pathway
Biological Processosteoclast differentiation
Biological Processpositive regulation of cell migration
Biological Processregulation of MAPK cascade

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    receptor protein-tyrosine kinase
  • EC number

Gene names

    • Name
      CSF1R

Organism names

Accessions

  • Primary accession
    A0A0H3WMK7

Subcellular Location

Cell membrane
; Single-pass type I membrane protein
Membrane
; Single-pass type I membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane519-539Helical

Keywords

  • Cellular component

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

TypeIDPosition(s)Description
Signal1-17
ChainPRO_500520324018-976receptor protein-tyrosine kinase
Disulfide bond47↔91
Disulfide bond137↔186
Disulfide bond233↔288
Disulfide bond429↔494

Keywords

Family & Domains

Features

Showing features for domain, compositional bias, region.

TypeIDPosition(s)Description
Domain212-304Ig-like
Domain315-406Ig-like
Domain422-512Ig-like
Domain583-917Protein kinase
Compositional bias920-954Basic and acidic residues
Region920-976Disordered

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    976
  • Mass (Da)
    109,762
  • Last updated
    2015-10-14 v1
  • Checksum
    F9DCFB7861C9CC2A
MFAVLFFCGILYGPAQGWSEPQIRLNSGALAGTDVILSSGSVLHLICEGEGPVTWIPQLAKNKRYISKEVGNIRSFHVERAKVDFTGTYKCIYMNASYSNVSSSVHVFVRGSQELFFSLSKTRPPVAKEGEDLLIPCLLTDPDATDFTLRMDNGSAMPYGMNATFDPRKGVLIRNVQPGFTADYVCSARIGGVEKMSKIFKVNIVQRLRFPPYVFLRRNEHVKLVGERLQIICTTNNPNFDYNVTWTHSTRKLPQAEEKSKMQGDRLAIESVLIIPAVQLSDSGNITCTGQNEAGANSSTTQLLVVGEPYIRLSPKLSSKLTHRGLSIEVREGDDVDLGVLIEAYPPLTSHQWVTPTSHNASLPENTFYNYNDRYEALLFLRRLNFQEIGRYTLHVKSSMKNASITFDIKMYKKPVATVRWENVTTLTCRSYGYPAPSILWYQCSGITTTCPENTTDLQPIQTQTVEFLKEPYGSVGVESVLTVGPNRRMTVVCVAFNLVGQGSDTFSMDVSDQLFTSTMYGCGVAMLVLALLLAIMFYKYKQKPRFEIRWKIIEATNGNNYTFIDPTQLPYNEKWEFPRDKLKLGKTLGAGAFGKVVEATAYGLGKEDNVTRVAVKMLKASAHPDEREALMSELKILSHLGQHKNIVNLLGACTHGGPVLVITEYCCHGDLLNFLRSKAENFLNFVMTIPNFPELATDYKNVNTDRMFVRSDSGISSTCSDNYLDMRPATSRPTNSVLGSSFECQAEDSWPLDMDDLLRFSYQVAQGLDFLAAKNCIHRDVAARNVLLTNSRVAKICDFGLARDIMNDSNYVVKGNARLPVKWMAPESIFECVYTVQSDVWSYGILLWEIFSLGKSPYPNILVDSKFYKMIKCGYQMTRPDFASPEMYTIMKMCWNLEAAERPTFSKIGQMIERMLGDAPDEQETEYKNLQSEEPSDEQPESCDPVKPEEETNETSCDQEEEDQPLMKANNYQFC

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias920-954Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KP244336
EMBL· GenBank· DDBJ
AKM12662.1
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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