A0A0H3W724 · A0A0H3W724_9SAUR

  • Protein
    mRNA decay activator protein ZFP36
  • Gene
    zfp36l1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Predicted
  • Annotation score
    2/5

Function

function

Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Cellular Componentribonucleoprotein complex
Molecular Functionmetal ion binding
Molecular FunctionmRNA 3'-UTR AU-rich region binding
Biological Process3'-UTR-mediated mRNA destabilization
Biological Processpositive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    mRNA decay activator protein ZFP36
  • Alternative names
    • Zinc finger protein 36

Gene names

    • Name
      zfp36l1

Organism names

  • Taxonomic identifier
  • Organism
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Lepidosauria > Squamata > Bifurcata > Unidentata > Episquamata > Toxicofera > Iguania > Phrynosomatidae > Phrynosomatinae > Phrynosoma

Accessions

  • Primary accession
    A0A0H3W724

Subcellular Location

Keywords

Interaction

Subunit

Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.

Family & Domains

Features

Showing features for domain, zinc finger, region, compositional bias.

Type
IDPosition(s)Description
Domain1-21C3H1-type
Zinc finger1-21C3H1-type
Region118-163Disordered
Compositional bias128-162Polar residues

Keywords

Family and domain databases

Sequence

  • Sequence status
    Fragment
  • Length
    179
  • Mass (Da)
    18,981
  • Last updated
    2015-10-14 v1
  • Checksum
    931E453F3E0F06DE
TFHTIGFCPYGPRCHFIHNAEERRAVAGSREAAITERPRLQHSFSFAGFPSAVAANGLLDSPTSITPPPIMSADDLLGSPTLPDCASNPFTFSSQELTNLFAPSMGVSVSGGGSPTAFLLRPMSESPNMFDSPPSPQDSLSDQEGYLSSSSSSHSGSDSPILDTSRRLPIFSRLSISDE

Features

Showing features for non-terminal residue, compositional bias.

Type
IDPosition(s)Description
Non-terminal residue1
Compositional bias128-162Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
KR360047
EMBL· GenBank· DDBJ
AKK51981.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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