A0A0H3PRF3 · A0A0H3PRF3_ECO5C

Function

function

Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.

Catalytic activity

Cofactor

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Pathway

Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1.

Features

Showing features for binding site, active site, site.

TypeIDPosition(s)Description
Binding site92substrate
Binding site96Mn2+ (UniProtKB | ChEBI)
Active site106Proton donor
Binding site106Mn2+ (UniProtKB | ChEBI)
Binding site108-110substrate
Binding site145Mn2+ (UniProtKB | ChEBI)
Binding site175Mn2+ (UniProtKB | ChEBI)
Site175Important for dimerization
Binding site258-260substrate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functioncoproporphyrinogen oxidase activity
Molecular Functionmanganese ion binding
Molecular Functionprotein homodimerization activity
Biological Processprotoporphyrinogen IX biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Oxygen-dependent coproporphyrinogen-III oxidase
  • EC number
  • Short names
    CPO
    ; Coprogen oxidase
    ; Coproporphyrinogenase

Gene names

    • Name
      hemF
    • ORF names
      ECH7EC869_5659

Organism names

Accessions

  • Primary accession
    A0A0H3PRF3

Proteomes

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region240-275Important for dimerization

Sequence similarities

Belongs to the aerobic coproporphyrinogen-III oxidase family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    299
  • Mass (Da)
    34,289
  • Last updated
    2015-09-16 v1
  • Checksum
    5D3F2C67ECF4192D
MKPDAHQVKQFLLNLQDTICQQLTAVDGAEFVEDSWQREGGGGGRSRVLRNGGVFEQAGVNFSHVHGEAMPASATAHRPELAGRSFEAMGVSLVVHPHNPYVPTSHANVRFFIAEKPGAEPVWWFGGGFDLTPFYGFEEDAIHWHRTARDLCLPFGKDVYPRYKKWCDDYFYLKHRNEQRGIGGLFFDDLNTPDFDHCFAFMQAVGKGYTDAYLPIVERRKAMAYGERERNFQLYRRGRYVEFNLVWDRGTLFGLQTGGRTESILMSMPPLVRWEYDYQPKDGSPEAALSEFIKVRDWV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
ABHU01000010
EMBL· GenBank· DDBJ
EDU90672.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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