A0A0H3PRF3 · A0A0H3PRF3_ECO5C
- ProteinOxygen-dependent coproporphyrinogen-III oxidase
- GenehemF
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids299 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX.
Catalytic activity
- coproporphyrinogen III + O2 + 2 H+ = protoporphyrinogen IX + 2 CO2 + 2 H2O
Cofactor
Pathway
Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1.
Features
Showing features for binding site, active site, site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 92 | substrate | ||||
Sequence: S | ||||||
Binding site | 96 | Mn2+ (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Active site | 106 | Proton donor | ||||
Sequence: H | ||||||
Binding site | 106 | Mn2+ (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 108-110 | substrate | ||||
Sequence: NVR | ||||||
Binding site | 145 | Mn2+ (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 175 | Mn2+ (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Site | 175 | Important for dimerization | ||||
Sequence: H | ||||||
Binding site | 258-260 | substrate | ||||
Sequence: GGR |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | coproporphyrinogen oxidase activity | |
Molecular Function | manganese ion binding | |
Molecular Function | protein homodimerization activity | |
Biological Process | protoporphyrinogen IX biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameOxygen-dependent coproporphyrinogen-III oxidase
- EC number
- Short namesCPO ; Coprogen oxidase ; Coproporphyrinogenase
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Escherichia
Accessions
- Primary accessionA0A0H3PRF3
Proteomes
Subcellular Location
Interaction
Subunit
Homodimer.
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 240-275 | Important for dimerization | ||||
Sequence: YVEFNLVWDRGTLFGLQTGGRTESILMSMPPLVRWE |
Sequence similarities
Belongs to the aerobic coproporphyrinogen-III oxidase family.
Family and domain databases
Sequence
- Sequence statusComplete
- Length299
- Mass (Da)34,289
- Last updated2015-09-16 v1
- Checksum5D3F2C67ECF4192D