A0A0H3MSA3 · A0A0H3MSA3_MYCLB

Function

function

A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl-inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for binding site.

129020406080100120140160180200220240260280
TypeIDPosition(s)Description
Binding site12Zn2+ (UniProtKB | ChEBI)
Binding site15Zn2+ (UniProtKB | ChEBI)
Binding site142Zn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Functionhydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
Molecular Functionzinc ion binding
Biological Processmycothiol metabolic process
Biological Processmycothiol-dependent detoxification

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Mycothiol S-conjugate amidase
  • EC number

Gene names

    • Name
      mca
    • Ordered locus names
      MLBr02391

Organism names

Accessions

  • Primary accession
    A0A0H3MSA3

Proteomes

Interaction

Subunit

Monomer.

Family & Domains

Sequence similarities

Belongs to the MshB deacetylase family. Mca subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    290
  • Mass (Da)
    32,575
  • Last updated
    2015-09-16 v1
  • Checksum
    16D80BB123DDB04F
MSELRLMAVHAHPDDESSKGAATLARYADEGHRVLVVTLTGGERGEILNPAMDLPDVHGHIAEIRRDEMAKAAEILGVEHTWLGFIDSGLPKGDPPPPLPDDCFALVPLEVCTEALVRVVRKFRPHVLTTYDENGGYPHPDHIRCHQVSVDAYEAACDYRRFPDAGKPWTVSKLYYNHGFLRARMQLLHDEFAKHGQAGPFDKWLAQSNPAHDPFESRVTTRVECSAYFSQRDDALRAHATQIDPKAEFFAAPISWQQRLWPTEEFELARSRVPTRLPEHDLFAGIEAAG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
FM211192
EMBL· GenBank· DDBJ
CAR72489.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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