A0A0H3MSA3 · A0A0H3MSA3_MYCLB
- ProteinMycothiol S-conjugate amidase
- Genemca
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids290 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl-inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics.
Catalytic activity
- mycothiol S-conjugate + H2O = an N-acetyl-L-cysteine-S-conjugate + 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside
Cofactor
Note: Binds 1 zinc ion per subunit.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 12 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 15 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 142 | Zn2+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides | |
Molecular Function | zinc ion binding | |
Biological Process | mycothiol metabolic process | |
Biological Process | mycothiol-dependent detoxification |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMycothiol S-conjugate amidase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Mycobacteriaceae > Mycobacterium
Accessions
- Primary accessionA0A0H3MSA3
Proteomes
Interaction
Subunit
Monomer.
Structure
Sequence
- Sequence statusComplete
- Length290
- Mass (Da)32,575
- Last updated2015-09-16 v1
- Checksum16D80BB123DDB04F
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
FM211192 EMBL· GenBank· DDBJ | CAR72489.1 EMBL· GenBank· DDBJ | Genomic DNA |