A0A0H3F6S5 · A0A0H3F6S5_RAHSY

  • Protein
    Xanthine-guanine phosphoribosyltransferase
  • Gene
    gpt
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines guanine and xanthine to form the corresponding ribonucleotides GMP (guanosine 5'-monophosphate) and XMP (xanthosine 5'-monophosphate), with the release of PPi. To a lesser extent, also acts on hypoxanthine.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Purine metabolism; GMP biosynthesis via salvage pathway; GMP from guanine: step 1/1.
Purine metabolism; XMP biosynthesis via salvage pathway; XMP from xanthine: step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site37-385-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site695-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site69GMP (UniProtKB | ChEBI)
Binding site88-965-phospho-alpha-D-ribose 1-diphosphate (UniProtKB | ChEBI)
Binding site89Mg2+ (UniProtKB | ChEBI)
Binding site92guanine (UniProtKB | ChEBI)
Binding site92xanthine (UniProtKB | ChEBI)
Binding site92-96GMP (UniProtKB | ChEBI)
Binding site134-135GMP (UniProtKB | ChEBI)
Binding site135guanine (UniProtKB | ChEBI)
Binding site135xanthine (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentplasma membrane
Molecular Functionguanine phosphoribosyltransferase activity
Molecular Functionhypoxanthine phosphoribosyltransferase activity
Molecular Functionmagnesium ion binding
Molecular Functionxanthine phosphoribosyltransferase activity
Biological ProcessGMP salvage
Biological ProcessIMP salvage
Biological Processpurine ribonucleoside salvage
Biological ProcessXMP salvage

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Xanthine-guanine phosphoribosyltransferase
  • EC number
  • Short names
    XGPRT
  • Alternative names
    • Xanthine phosphoribosyltransferase

Gene names

    • Name
      gpt
    • Ordered locus names
      Rahaq_0958

Organism names

  • Taxonomic identifier
  • Strain
    • Y9602
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Yersiniaceae > Rahnella

Accessions

  • Primary accession
    A0A0H3F6S5

Proteomes

Subcellular Location

Cell inner membrane
; Peripheral membrane protein

Keywords

Interaction

Subunit

Homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain12-143Phosphoribosyltransferase

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    152
  • Mass (Da)
    16,988
  • Last updated
    2015-09-16 v1
  • Checksum
    DF5BFD081AE171A6
MSEKYVVTWDMLQIHARTMAKRLLPAEQWKGIIAVSRGGLVPAALLARELCIRHVDTVCISSYDHDNQREMQVLKRAEGDGEGFIVIDDLVDTGGTAKAIREMYPKAHFITIFAKPAGAPLVDDYVIDIPQNTWIEQPWDMGVVFVPPLVGK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP002505
EMBL· GenBank· DDBJ
ADW72583.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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