A0A0H3C0S6 · A0A0H3C0S6_STRPZ

Function

function

CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Features

Showing features for binding site.

134150100150200250300
TypeIDPosition(s)Description
Binding site165Mn2+ (UniProtKB | ChEBI)
Binding site233Mn2+ (UniProtKB | ChEBI)
Binding site248Mn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular FunctionDNA binding
Molecular FunctionDNA endonuclease activity
Molecular Functionmetal ion binding
Biological Processdefense response to virus
Biological Processmaintenance of CRISPR repeat elements

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    CRISPR-associated endonuclease Cas1
  • EC number

Gene names

    • Name
      cas1
    • Ordered locus names
      Spy49_1208c

Organism names

Accessions

  • Primary accession
    A0A0H3C0S6

Proteomes

Interaction

Subunit

Homodimer, forms a heterotetramer with a Cas2 homodimer.

Family & Domains

Sequence similarities

Belongs to the CRISPR-associated endonuclease Cas1 family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    341
  • Mass (Da)
    39,584
  • Last updated
    2015-09-16 v1
  • MD5 Checksum
    AEA39A1A6BE2EFF1BD0C0DD966CC4B5B
MKKLLNTLYLTQEDFYVTKEGDNIVIKQEGKVLKRFPFRIIDGIVCFSYLGVSSALVKLCTENQINLSFHTPQGRFCGRYIGSTNGNVLLRREHYRLSDREESLEYAKRFILAKISNSRKYLLRFKRDHRQQIDTKLFEAVNDELIWALEMVQAADNKDSLRGIEGQAANQYFRIFNDLVLTDKKTFYFQGRSKRPPLDCVNALLSFGYSLLTFECQSALEAVGLDSYVGFFHTDRPGRASLALDLVEEFRSYIVDRFVFSLINKGQLQKKHFEVKENGSILLTENGRAIFIDLWQKRKHTEVEHPFTKEKVKLMLLPYVQAQLLAKAIRGDLESYPPFMV

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000829
EMBL· GenBank· DDBJ
ACI61496.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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