A0A0H3BZ80 · A0A0H3BZ80_STRPZ
- ProteinPyruvate formate-lyase-activating enzyme
- GenepflC
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids287 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.
Catalytic activity
- glycyl-[formate C-acetyltransferase] + reduced [flavodoxin] + S-adenosyl-L-methionine = glycin-2-yl radical-[formate C-acetyltransferase] + semiquinone [flavodoxin] + 5'-deoxyadenosine + L-methionine + H+
Cofactor
Note: Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | 4 iron, 4 sulfur cluster binding | |
Molecular Function | [formate-C-acetyltransferase]-activating enzyme activity | |
Molecular Function | lyase activity | |
Molecular Function | metal ion binding |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePyruvate formate-lyase-activating enzyme
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacillota > Bacilli > Lactobacillales > Streptococcaceae > Streptococcus
Accessions
- Primary accessionA0A0H3BZ80
Proteomes
Subcellular Location
Structure
Family & Domains
Sequence
- Sequence statusComplete
- Length287
- Mass (Da)33,125
- Last updated2015-09-16 v1
- ChecksumE6425425E0603EE6
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000829 EMBL· GenBank· DDBJ | ACI60650.1 EMBL· GenBank· DDBJ | Genomic DNA |