KChIP1 plays a neuroprotective role against 4-AP acute induced cell death in primary hippocampal cells through regulation of Kv 4.3 and GABA transmission but this is lost after long term exposure.
KChIP1 is selectively expressed in BLA interneurons where it may function to regulate the activity of A-type potassium channels. Hence KChIP1 might be considered as a specific regulator of GABAergic inhibitory circuits in the basolateral amygdala.
Aph1b and KCnIP1 are significantly differentially expressed in a number of brain tissues of a schizophrenia model; KCnIP1 is an attractive novel candidate gene that may play a role in the complex phenotype
PUFAs inhibit Kv4/KChIP channels by facilitating inactivation from open and closed gating states and access of the fatty acid to the internal leaflet of the membrane is important
KChIP1 coassociates with Kv4 subunits in hippocampal membranes confirming that the KChIPs are tightly associated with Kv4 subunits in native brain A-type channel complexes which may play a major role as modulators of somatodendritic excitability..
The features of KChIP1b modulation of Kv4 channels are likely to be conserved in mammals and demonstrate a role for the KChIP1 NH2-terminal region in the regulation of closed inactivation gating.
hypothesis that occlusion of the inner vestibule of the Na(+) channel by the fast inactivation gate inhibits ultra-slow inactivation (mu1 sodium channel)
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