A0A0G9FDF4 · A0A0G9FDF4_LACPN

Function

function

Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.

Catalytic activity

Activity regulation

Activated by phosphorylation and inhibited by fructose 1,6-bisphosphate (FBP).

Pathway

Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.

Features

Showing features for binding site.

150550100150200250300350400450500
TypeIDPosition(s)Description
Binding site13ADP (UniProtKB | ChEBI)
Binding site13ATP (UniProtKB | ChEBI)
Binding site13sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site14ATP (UniProtKB | ChEBI)
Binding site15ATP (UniProtKB | ChEBI)
Binding site17ADP (UniProtKB | ChEBI)
Binding site83glycerol (UniProtKB | ChEBI)
Binding site83sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site84glycerol (UniProtKB | ChEBI)
Binding site84sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site135glycerol (UniProtKB | ChEBI)
Binding site135sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site245glycerol (UniProtKB | ChEBI)
Binding site245sn-glycerol 3-phosphate (UniProtKB | ChEBI)
Binding site246glycerol (UniProtKB | ChEBI)
Binding site267ADP (UniProtKB | ChEBI)
Binding site267ATP (UniProtKB | ChEBI)
Binding site310ADP (UniProtKB | ChEBI)
Binding site310ATP (UniProtKB | ChEBI)
Binding site314ATP (UniProtKB | ChEBI)
Binding site411ADP (UniProtKB | ChEBI)
Binding site411ATP (UniProtKB | ChEBI)
Binding site415ADP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionATP binding
Molecular Functionglycerol kinase activity
Biological Processglycerol catabolic process
Biological Processglycerol-3-phosphate metabolic process
Biological Processphosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Glycerol kinase
  • EC number
  • Alternative names
    • ATP:glycerol 3-phosphotransferase
    • Glycerokinase
      (GK
      )

Gene names

    • Name
      glpK
    • ORF names
      AYO51_03905
      , JH395_01595
      , Lp19_1676
      , LPJSA22_00347
      , NAB2_1454

Organism names

Accessions

  • Primary accession
    A0A0G9FDF4

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for modified residue.

TypeIDPosition(s)Description
Modified residue231Phosphohistidine; by HPr

Post-translational modification

The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), including enzyme I, and histidine-containing protein (HPr) are required for the phosphorylation, which leads to the activation of the enzyme.

Keywords

Interaction

Subunit

Homotetramer and homodimer (in equilibrium).

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain5-252Carbohydrate kinase FGGY N-terminal
Domain262-449Carbohydrate kinase FGGY C-terminal

Sequence similarities

Belongs to the FGGY kinase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    505
  • Mass (Da)
    55,818
  • Last updated
    2015-09-16 v1
  • Checksum
    09D135885F9AB76A
MTDKYIMAIDEGTTSTRAIIFDHAGHKVADSQREFPQYFPQPGWVEHNANEIWNAVLSTIANAFIESGIKPAQISGIGITNQRETTIVWDKQTGLPIYNAIVWQSRQTAPIAEKLVKDGYGDLIHQHTGLVTDAYFSATKIRWILDHVKGAQERAEKGELLFGTIDTWLLWKLTGGATHVTDYSNASRTMLFNIHDLKWDDQILQLLNIPAAMLPEVRTNSEVYGKTKDYHFFGSEVPISGMAGDQQAALFGQLAFEPGTVKNTYGTGAFIVMNTGEKPQLSDNNLLTTIGYGINGKVYYALEGSIFVAGSAIQWLRDGIRLVESAPDSERAARESHNENEVYVVPAFTGLGAPYWDSEARGSVFGLTRGTTREDFIKATLQALAYQTRDVVETMKKDSGIEIPVLKVDGGAARNDWLMQFQADILDTQIMRAANLETTALGAAFLAGLSVGYWQDLEELKASYKPGTSFDPEMGPAERTNLYEGWQAAVKATQVFKHTPYHAGK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
LSST01000033
EMBL· GenBank· DDBJ
KYK52902.1
EMBL· GenBank· DDBJ
Genomic DNA
LUXM01000028
EMBL· GenBank· DDBJ
KZU94887.1
EMBL· GenBank· DDBJ
Genomic DNA
LUXO01000025
EMBL· GenBank· DDBJ
KZV03446.1
EMBL· GenBank· DDBJ
Genomic DNA
MCOL01000001
EMBL· GenBank· DDBJ
ODO60414.1
EMBL· GenBank· DDBJ
Genomic DNA
CP066817
EMBL· GenBank· DDBJ
QQM61275.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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