A0A0G8XVR7 · A0A0G8XVR7_XANPE
- ProteinAspartate 1-decarboxylase
- GenepanD
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids126 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
Catalytic activity
- L-aspartate + H+ = beta-alanine + CO2
Cofactor
Note: Binds 1 pyruvoyl group covalently per subunit.
Pathway
Cofactor biosynthesis; (R)-pantothenate biosynthesis; beta-alanine from L-aspartate: step 1/1.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 25 | Schiff-base intermediate with substrate; via pyruvic acid | ||||
Sequence: S | ||||||
Binding site | 57 | substrate | ||||
Sequence: T | ||||||
Active site | 58 | Proton donor | ||||
Sequence: Y | ||||||
Binding site | 73-75 | substrate | ||||
Sequence: GGA |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | aspartate 1-decarboxylase activity | |
Biological Process | alanine biosynthetic process | |
Biological Process | pantothenate biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAspartate 1-decarboxylase
- EC number
- Alternative names
- Cleaved into 2 chains
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Lysobacterales > Lysobacteraceae > Xanthomonas
Accessions
- Primary accessionA0A0G8XVR7
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_5042622509 | 1-24 | Aspartate 1-decarboxylase beta chain | |||
Sequence: MHLSLLKAKIHRATVTHSELNYEG | ||||||
Modified residue | 25 | Pyruvic acid (Ser) | ||||
Sequence: S | ||||||
Chain | PRO_5042622508 | 25-126 | Aspartate 1-decarboxylase alpha chain | |||
Sequence: SIAIDGLLLEATGIREFEQVHIWDVTNGARFSTYAIRAEEGSGIMSLNGGAARHVQVGDLIIVAAFASMSEDEAKTFKPNLVYVNAHNAISHTNHSIPTQAA |
Post-translational modification
Is synthesized initially as an inactive proenzyme, which is activated by self-cleavage at a specific serine bond to produce a beta-subunit with a hydroxyl group at its C-terminus and an alpha-subunit with a pyruvoyl group at its N-terminus.
Keywords
- PTM
Interaction
Subunit
Heterooctamer of four alpha and four beta subunits.
Structure
Sequence
- Sequence statusComplete
- Length126
- Mass (Da)13,637
- Last updated2015-09-16 v1
- Checksum64EC1BF390E58624
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
JAAGYU010000049 EMBL· GenBank· DDBJ | NEL76991.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
PUUL01000146 EMBL· GenBank· DDBJ | RXD49366.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
SMVF01000060 EMBL· GenBank· DDBJ | TVS46775.1 EMBL· GenBank· DDBJ | Genomic DNA |