A0A0G4FUI8 · A0A0G4FUI8_VITBC

Function

function

Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Note: Binds 1 divalent metal cation per subunit; can use either Mg2+ or Mn2+.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site107-112ITP (UniProtKB | ChEBI)
Binding site135Mg2+ (UniProtKB | ChEBI)
Binding site147ITP (UniProtKB | ChEBI)
Binding site163Mg2+ (UniProtKB | ChEBI)
Binding site163-164ITP (UniProtKB | ChEBI)
Binding site239-242ITP (UniProtKB | ChEBI)
Binding site262ITP (UniProtKB | ChEBI)
Binding site267-268ITP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctiondITP diphosphatase activity
Molecular FunctionITP diphosphatase activity
Molecular Functionmetal ion binding
Molecular Functionnucleotide binding
Molecular FunctionXTP diphosphatase activity
Biological Processdeoxyribonucleoside triphosphate catabolic process
Biological Processnucleotide metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Inosine triphosphate pyrophosphatase
  • EC number
  • Short names
    ITPase
    ; Inosine triphosphatase
  • Alternative names
    • Non-canonical purine NTP pyrophosphatase
    • Non-standard purine NTP pyrophosphatase
    • Nucleoside-triphosphate diphosphatase
    • Nucleoside-triphosphate pyrophosphatase
      (NTPase
      )

Gene names

    • ORF names
      Vbra_4488

Organism names

Accessions

  • Primary accession
    A0A0G4FUI8

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the HAM1 NTPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    299
  • Mass (Da)
    33,173
  • Last updated
    2015-09-16 v1
  • Checksum
    EDB3CF296C48783C
MSPGRQGHCTFIADLIISAKVCSVVVLSLLPAVLQRTPIGASAFRLTERVIRPFHRSRSRQGAGRLSLYPDHLSRTALELTPVEPAVMADDMCVTEKGKEMVLCFCTGNANKLREVSFILGKTVTLTSADVDLPELQGDPADISVGKCRLAFNQLKQPVIVEDTSLCFNALGGLPGPYVKWFLKKLGHKDLPKLLAGFDDKSAYALCMFSYMDDTLEKPLLFEGRTNGVIVDARGDPNFGWDPIFQPHGFDQTYAEMTKELKNTISHRYRALEKLKTYLVQHKEEFLTAHAAKKVKSGE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CDMY01000504
EMBL· GenBank· DDBJ
CEM18606.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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