A0A0G3UG63 · A0A0G3UG63_9ACTN

  • Protein
    GMP reductase
  • Gene
    guaB1
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Involved in the purine-salvage pathway. Catalyzes the NADPH-dependent conversion of GMP to IMP.

Catalytic activity

Cofactor

a monovalent cation (UniProtKB | Rhea| CHEBI:60242 )

Pathway

Purine metabolism; IMP biosynthesis via salvage pathway.

Features

Showing features for binding site, active site.

148050100150200250300350400450
TypeIDPosition(s)Description
Binding site246-248NAD+ (UniProtKB | ChEBI)
Binding site246-248NADP+ (UniProtKB | ChEBI)
Binding site296-298NAD+ (UniProtKB | ChEBI)
Binding site296-298NADP+ (UniProtKB | ChEBI)
Binding site298K+ (UniProtKB | ChEBI); ligand shared between two tetrameric partners; in other chain
Binding site300K+ (UniProtKB | ChEBI); ligand shared between two tetrameric partners; in other chain
Active site303Thioimidate intermediate
Binding site303K+ (UniProtKB | ChEBI); ligand shared between two tetrameric partners; in other chain

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionGMP reductase activity
Molecular FunctionIMP dehydrogenase activity
Biological ProcessIMP salvage
Biological Processpurine ribonucleoside salvage

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    GMP reductase
  • EC number
  • Alternative names
    • Guanosine 5'-monophosphate reductase
      (GMPR
      )

Gene names

    • Name
      guaB1
    • ORF names
      M444_07500

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Mg1
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Kitasatosporales > Streptomycetaceae > Streptomyces

Accessions

  • Primary accession
    A0A0G3UG63

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain95-152CBS
Domain154-210CBS

Sequence similarities

Belongs to the IMPDH/GMPR family. GuaB1 subfamily.

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    480
  • Mass (Da)
    50,657
  • Last updated
    2015-09-16 v1
  • Checksum
    0026D0777326AC51
MRFLNDLKPPYDLTYDDVFMVPSRSAVGSRQGVDLSSPDGTGTTIPLVVANMTAIAGRRMAETVARRGGIVVIPQDIPIEVVTDVISWVKTRHHVLDTPITLAPTQTVADALSLLPKRAHGAGVVVDAENRPVGVVTDHDLTGVDRFTQLSEVMSKELLLIDADIDPRQAFNQLDAGHRKLAPAVDKDGRLVGILTRKGALRATLYAPAVDAKGGLRIAAAVGINGDFVGKAKQLLDAGVDTIVIDTAHGHQESMINAIKAVRALDPQVPIVAGNIVAAEGVKDLIDAGADIIKVGVGPGAMCTTRMMTGVGRPQFSAVLECAAEAKKYGKHVWADGGVRHPRDVAMALAAGASNVMIGSWFAGTYESPGDLQQSADGRFYKESFGMASARAVQNRTSEESAYDRARKGLFEEGISTSRMFLDPARPGVEDLIDSIIAGVRSSCTYAGAGSLAEFEEKAVVGIQSAAGYAEGKPLHASWS

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP011664
EMBL· GenBank· DDBJ
AKL65259.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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