A0A0G3HEM8 · A0A0G3HEM8_9CORY
- ProteindITP/XTP pyrophosphatase
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids208 (go to sequence)
- Protein existenceInferred from homology
- Annotation score4/5
Function
function
Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.
Catalytic activity
- H2O + ITP = diphosphate + H+ + IMP
Cofactor
Note: Binds 1 Mg2+ ion per subunit.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 7-12 | substrate | ||||
Sequence: SNNSKK | ||||||
Active site | 72 | Proton acceptor | ||||
Sequence: D | ||||||
Binding site | 72 | Mg2+ (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 73 | substrate | ||||
Sequence: S | ||||||
Binding site | 155-158 | substrate | ||||
Sequence: FGYD | ||||||
Binding site | 184 | substrate | ||||
Sequence: K | ||||||
Binding site | 189-190 | substrate | ||||
Sequence: HR |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | dITP diphosphatase activity | |
Molecular Function | ITP diphosphatase activity | |
Molecular Function | metal ion binding | |
Molecular Function | nucleotide binding | |
Molecular Function | ribonucleoside triphosphate phosphatase activity | |
Molecular Function | XTP diphosphatase activity | |
Biological Process | nucleotide metabolic process | |
Biological Process | purine nucleoside triphosphate catabolic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namedITP/XTP pyrophosphatase
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Corynebacteriaceae > Corynebacterium
Accessions
- Primary accessionA0A0G3HEM8
Proteomes
Interaction
Structure
Sequence
- Sequence statusComplete
- Length208
- Mass (Da)21,337
- Last updated2015-09-16 v1
- ChecksumC6E8BB349FBAE7ED
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP011546 EMBL· GenBank· DDBJ | AKK11749.1 EMBL· GenBank· DDBJ | Genomic DNA |