A0A0G3ATH6 · A0A0G3ATH6_9ACTN

  • Protein
    Transcriptional regulator WhiB
  • Gene
    whiB
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    2/5

Function

function

Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.

Features

Showing features for binding site.

1831020304050607080MDNWRDHAACRHEDPDLFFPIGTTGPALVQTQRAKAVCGRCPVQEECLDWALETGQGIGVWGGTTELERRALHRRARSRPRSG
TypeIDPosition(s)Description
Binding site10[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site38[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site41[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site47[4Fe-4S] cluster (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functiondinitrosyl-iron complex binding
Molecular FunctionDNA binding
Molecular Functionmetal ion binding
Molecular Functionprotein-disulfide reductase (NAD(P)H) activity
Biological Processcell redox homeostasis
Biological Processnegative regulation of DNA-templated transcription

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Transcriptional regulator WhiB

Gene names

    • Name
      whiB
    • ORF names
      ABB07_35090

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • NRRL8089
  • Taxonomic lineage
    Bacteria > Actinomycetota > Actinomycetes > Kitasatosporales > Streptomycetaceae > Streptomyces

Accessions

  • Primary accession
    A0A0G3ATH6

Proteomes

Subcellular Location

Keywords

PTM/Processing

Post-translational modification

The Fe-S cluster can be nitrosylated by nitric oxide (NO).
Upon Fe-S cluster removal intramolecular disulfide bonds are formed.

Keywords

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain9-714Fe-4S Wbl-type

Sequence similarities

Belongs to the WhiB family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    83
  • Mass (Da)
    9,299
  • Last updated
    2015-09-16 v1
  • MD5 Checksum
    8D7AA00A344EEC55D85775630CB5D86E
MDNWRDHAACRHEDPDLFFPIGTTGPALVQTQRAKAVCGRCPVQEECLDWALETGQGIGVWGGTTELERRALHRRARSRPRSG

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP011497
EMBL· GenBank· DDBJ
AKJ15100.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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