A0A0G3AAF2 · A0A0G3AAF2_9ACTN
- ProteinAlpha-ketoglutarate decarboxylase
- Genekgd
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids1269 (go to sequence)
- Protein existencePredicted
- Annotation score3/5
Function
Catalytic activity
- N6-[(R)-lipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + 2-oxoglutarate + H+ = N6-[(R)-S8-succinyldihydrolipoyl]-L-lysyl-[dihydrolipoyllysine-residue succinyltransferase] + CO2
Cofactor
Protein has several cofactor binding sites:
Pathway
Carbohydrate metabolism; tricarboxylic acid cycle; succinyl-CoA from 2-oxoglutarate (dehydrogenase route): step 1/1.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Cellular Component | oxoglutarate dehydrogenase complex | |
Molecular Function | dihydrolipoyllysine-residue succinyltransferase activity | |
Molecular Function | lyase activity | |
Molecular Function | magnesium ion binding | |
Molecular Function | oxoglutarate dehydrogenase (succinyl-transferring) activity | |
Molecular Function | thiamine pyrophosphate binding | |
Biological Process | tricarboxylic acid cycle |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Kitasatosporales > Streptomycetaceae > Streptomyces
Accessions
- Primary accessionA0A0G3AAF2
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for compositional bias, region, coiled coil, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 1-17 | Polar residues | |||
Region | 1-25 | Disordered | |||
Region | 64-143 | Disordered | |||
Compositional bias | 87-128 | Pro residues | |||
Coiled coil | 832-859 | ||||
Domain | 921-1114 | Transketolase-like pyrimidine-binding | |||
Region | 1239-1258 | Disordered | |||
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,269
- Mass (Da)138,866
- Last updated2015-09-16 v1
- Checksum0F21DA194FD7A703
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 1-17 | Polar residues | |||
Compositional bias | 87-128 | Pro residues | |||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP011497 EMBL· GenBank· DDBJ | AKJ10851.1 EMBL· GenBank· DDBJ | Genomic DNA |