A0A0G2T365 · A0A0G2T365_EROTE
- ProteinUbiquinone biosynthesis monooxygenase COQ6, mitochondrial
- GeneOXase
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids511 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
function
FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.
Catalytic activity
- 4-hydroxy-3-all-trans-hexaprenylbenzoate + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H+ = 3,4-dihydroxy-5-all-trans-hexaprenylbenzoate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O
Cofactor
Pathway
Cofactor biosynthesis; ubiquinone biosynthesis.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | extrinsic component of mitochondrial inner membrane | |
Molecular Function | 4-hydroxy-3-all-trans-hexaprenylbenzoate oxygenase activity | |
Molecular Function | FAD binding | |
Molecular Function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | |
Biological Process | carotene biosynthetic process | |
Biological Process | ubiquinone biosynthetic process | |
Biological Process | xanthophyll biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameUbiquinone biosynthesis monooxygenase COQ6, mitochondrial
- EC number
Gene names
Organism names
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Geraniales > Geraniaceae > Erodium
Accessions
- Primary accessionA0A0G2T365
Subcellular Location
UniProt Annotation
GO Annotation
Mitochondrion inner membrane ; Peripheral membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 56-77 | Helical | ||||
Sequence: YDVAIVGGGMVGMALACSLASM |
Keywords
- Cellular component
Interaction
Subunit
Component of a multi-subunit COQ enzyme complex.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 56-330 | FAD-binding | ||||
Sequence: YDVAIVGGGMVGMALACSLASMPLTKQLNVAIIDSNPALQSKLLIKKEDPPDPRVSTVTPATINLFKDVGAWEYVLQHRHAFFDAMQVWDYTGLGYTRYDARDIGKEALGCVVENKVLHHALLSCLQNTELHKTIYPSRLTSMAIHRSSSSTHVDSTSTTTTLHSRGNLAKLELSDGSNLYAKLVVGSDGGKSHVRELAGFKTTGWSYPQNAIICTVEHTLENHCAWQRFLPSGPIALLPVGDNYSNIVWTMSPKEASERNSMDEDDFVKALNHA | ||||||
Domain | 380-454 | FAD-binding | ||||
Sequence: MFPLSLKHANDYASKRVALIGDAAHTIHPLAGQGVNLGFGDAFALSRVIAEGIAVGTDIGEVSLLKKYEAERKQA |
Sequence similarities
Belongs to the UbiH/COQ6 family.
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length511
- Mass (Da)55,634
- Last updated2015-09-16 v1
- ChecksumB85CB195F7D05F89