A0A0G2KHX4 · A0A0G2KHX4_DANRE
- ProteinTSC complex subunit 2
- Genetsc2
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids1674 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Cellular Component | TSC1-TSC2 complex | |
Molecular Function | GTPase activator activity | |
Biological Process | intestinal epithelial cell differentiation | |
Biological Process | negative regulation of insulin receptor signaling pathway | |
Biological Process | negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction | |
Biological Process | negative regulation of TOR signaling | |
Biological Process | negative regulation of Wnt signaling pathway | |
Biological Process | regulation of action potential firing pattern | |
Biological Process | regulation of cell cycle | |
Biological Process | regulation of small GTPase mediated signal transduction |
Keywords
- Molecular function
Names & Taxonomy
Protein names
- Submitted names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio
Accessions
- Primary accessionA0A0G2KHX4
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Proteomic databases
Expression
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for repeat, region, compositional bias, domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Repeat | 322-360 | HEAT | ||||
Sequence: VIPQLGQIAEDRDPSVRKQATQLLVDLAEGCSTHHFSSL | ||||||
Region | 481-508 | Disordered | ||||
Sequence: ESEKRVSEKKPTGSVSPPAGSPTPAAPP | ||||||
Compositional bias | 765-789 | Polar residues | ||||
Sequence: FRARSTSLNERPKSLRTTKVAKQGP | ||||||
Region | 765-793 | Disordered | ||||
Sequence: FRARSTSLNERPKSLRTTKVAKQGPSANS | ||||||
Region | 919-1024 | Disordered | ||||
Sequence: RHGGGEMTRSDPSLHTRQTKEAPAKLESQSSQQINTNTRTRVRSISGGHALRAGPAQSLSPLVASPEGEYSGPLPPPGPPLDVLSSQRGMEEHPPPSACNPSPPLK | ||||||
Compositional bias | 920-940 | Basic and acidic residues | ||||
Sequence: HGGGEMTRSDPSLHTRQTKEA | ||||||
Compositional bias | 941-962 | Polar residues | ||||
Sequence: PAKLESQSSQQINTNTRTRVRS | ||||||
Region | 1088-1117 | Disordered | ||||
Sequence: KEPPAERPTDVSQPQGKPAPIQRSNTVASL | ||||||
Compositional bias | 1102-1117 | Polar residues | ||||
Sequence: QGKPAPIQRSNTVASL | ||||||
Region | 1147-1268 | Disordered | ||||
Sequence: SMASVSPAESKEVEEFEAVPSEPIFMNTSTTAPGMMSRSSSTSSQDDDKSTLEEVSEGGIPIDQPPLSLCTPGAQDPELSFTQSSSSSSTLNKSSSSPELQTLPEAFSKASSQSVDPAPTSK | ||||||
Compositional bias | 1169-1192 | Polar residues | ||||
Sequence: PIFMNTSTTAPGMMSRSSSTSSQD | ||||||
Compositional bias | 1221-1267 | Polar residues | ||||
Sequence: QDPELSFTQSSSSSSTLNKSSSSPELQTLPEAFSKASSQSVDPAPTS | ||||||
Region | 1280-1356 | Disordered | ||||
Sequence: GESAGSTAGTSCSSSSVSVSSSSTSRMRLEFPPVQTGPLSPTGHRPRGHTISVSAPSSRRDRKTLERDARGGATNVE | ||||||
Compositional bias | 1283-1309 | Polar residues | ||||
Sequence: AGSTAGTSCSSSSVSVSSSSTSRMRLE | ||||||
Compositional bias | 1338-1352 | Basic and acidic residues | ||||
Sequence: RRDRKTLERDARGGA | ||||||
Domain | 1396-1623 | Rap-GAP | ||||
Sequence: VKVLDQMPPYDTHKIGVVFVGAGQANNEVSILSNEYGSKRYAQFLTGLGKLIHLKDCDPDQIFLGGLDQYGDDGEFTYCWHDDIMQAIFHIATLMPNRESDRGCCNKKRHIGNDFVVVVYNDSGEDYKLGTIKGQFNFVEVLIKPLDYESNLVTLQCRKDLEGLVDTSVAKIVSDRNLPLLVRQMALHANMASLVHQCRANPSDAYASKWLARLRHIKRIRTRAQEEI | ||||||
Region | 1620-1660 | Disordered | ||||
Sequence: QEEIQSRPSHGISLTQGHASMQNKPAHQPPGAAQNPDAGQR | ||||||
Compositional bias | 1624-1648 | Polar residues | ||||
Sequence: QSRPSHGISLTQGHASMQNKPAHQP |
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,674
- Mass (Da)184,482
- Last updated2015-07-22 v1
- ChecksumC453E11BEEC5C8C3
Computationally mapped potential isoform sequences
There are 4 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8M9PW15 | A0A8M9PW15_DANRE | tsc2 | 1841 | ||
A0A8M9Q1U8 | A0A8M9Q1U8_DANRE | tsc2 | 1107 | ||
A0A8M9PW05 | A0A8M9PW05_DANRE | tsc2 | 1130 | ||
A0A8M9PW10 | A0A8M9PW10_DANRE | tsc2 | 1087 |
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 765-789 | Polar residues | ||||
Sequence: FRARSTSLNERPKSLRTTKVAKQGP | ||||||
Compositional bias | 920-940 | Basic and acidic residues | ||||
Sequence: HGGGEMTRSDPSLHTRQTKEA | ||||||
Compositional bias | 941-962 | Polar residues | ||||
Sequence: PAKLESQSSQQINTNTRTRVRS | ||||||
Compositional bias | 1102-1117 | Polar residues | ||||
Sequence: QGKPAPIQRSNTVASL | ||||||
Compositional bias | 1169-1192 | Polar residues | ||||
Sequence: PIFMNTSTTAPGMMSRSSSTSSQD | ||||||
Compositional bias | 1221-1267 | Polar residues | ||||
Sequence: QDPELSFTQSSSSSSTLNKSSSSPELQTLPEAFSKASSQSVDPAPTS | ||||||
Compositional bias | 1283-1309 | Polar residues | ||||
Sequence: AGSTAGTSCSSSSVSVSSSSTSRMRLE | ||||||
Compositional bias | 1338-1352 | Basic and acidic residues | ||||
Sequence: RRDRKTLERDARGGA | ||||||
Compositional bias | 1624-1648 | Polar residues | ||||
Sequence: QSRPSHGISLTQGHASMQNKPAHQP |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CABZ01043817 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CABZ01043818 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CABZ01113995 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CABZ01113996 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
FO681319 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
FQ311887 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |